Foodconsumer.org


All News 
 
 Misc. News
 F.eatured P.roducts
 R.ecalls & A.lerts
 C.onsumer A.ffair
 Non-f.ood Things
 L.etter to E.ditor
 H.ealth T.ips
 Interesting Sites
 
 D.iet & H.ealth
 H.eart & B.lood
 C.ancer
 B.ody W.eight
 C.hildren & W.omen
 G.eneral H.ealth
 N.utrition
 
 F.ood & H.ealth
 F.ood C.hemicals
 B.iological A.gents
 C.ooking & P.acking
 T.echnologies
 Agri. & Environ.
 L.aws & P.olitics
 
 F.ood C.onsumer
 FC News & Others
Search


Newsfeed foodconsumer.org news feed

FC InsiderNews



Submit news[release]
PT writers wanted



Sponsors' link
profood - food ingredients supplier
shopseek shop dir.
infoplus web dir.

D.iet & H.ealth : G.eneral H.ealth Last Updated: Nov 27th, 2006 - 00:32:11


Plumeria acuminata leaves antiinflammatory
By
Nov 25, 2006, 13:22

E.mail t.his a.rticle
 P.rinter f.riendly p.age
Get n.ewsletter
 
   
M Gupta1 , UK Mazumder1 , P Gomathi2 and V Thamil Selvan1
1Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India
2Department of Pharmaceutical Chemistry, ASN Pharmacy college, Burripalem road, Nelapadu, Tenali, Andhra Pradesh, India

BMC Complementary and Alternative Medicine 2006, 6:36 doi:10.1186/1472-6882-6-36


© 2006 Gupta et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Backround

Plumeria acuminata belonging to the family Apocynaceae is commonly known as 'perungalli' in Tamil and is widely distributed throughout the Southern parts of India. In traditional medicinal system different parts of the plant have been mentioned to be useful in a variety of diseases. The plant material is widely used as a purgative, remedy for diarrhoea and cure for itch. The milky juice is employed for the treatment of inflammation and rheumatism. The bark has been reported to be useful in hard tumors, diarrhoea and gonorrhoea. The objective of the present study was to evaluate the antiinflammatory activity of methanol extract of leaves of Plumeria acuminata on carrageenan, dextran, histamine and serotonin-induced inflammation in rat hind paw oedema models.

Methods

Acute and chronic inflammation models were used to evaluate the anti-inflammatory activity of the extract. Wistar albino rats of either sex weighing 180–200 g were used. In acute model carrageenan, dextran, histamine and serotonin models were used to induce inflammation in rat hind paw and cotton pellet-induced granuloma method was used for chronic inflammation model. In each model four groups of six animals were used. In all the models Group I served as control (0.9% normal saline, 5 mlkg-1 b.w) and group IV as standard (Indomethacin 10 mgkg-1 b.w). Group II and III received extract at the doses of 250 and 500 mgkg-1 b.w respectively.

Results

The methanol extract of Plumeria acuminata exhibited significant anti-inflammatory activity on the tested experimental animal models. The extract (500 mgkg-1 b.w) exhibited maximum antiinflammatory effect i.e., 30.51, 47.06, 34.48 and 32.50% (P < 0.001) at the end of 3 h with carrageenan, dextran, histamine and serotonin respectively. Administration of MEPA (500 mgkg-1 b.w) and indomethacin (10 mgkg-1 b.w) significantly reduced the formation of granuloma tissue induced by cotton pellet method at a rate of 45.06 and 51.57% respectively. The effect produced by the extract was comparable to that of indomethacin a prototype of a nonsteroidal antiinflammatory agent.

Conclusion

The results obtained in this study indicated that the methanol extract of Plumeria acuminata possess potent antiinflammatory activity in both acute and chronic models.

Republished from http://www.biomedcentral.com/1472-6882/6/36




© 2004-2005 by foodconsumer.org unless otherwise specified

Top of Page







Google
 
Web foodconsumer.org
Disclaimer | Advertising | Jobs | Privacy | About US | FC InsiderNews
© 2004-2006 foodconsumer.org™ all rights reserved
Get newsFeed on your site.