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Doctors
in Berlin said a man was cured of AIDS after he received bone marrow transplant
from a donor naturally resistant to HIV virus.
The man had been negative for HIV for nearly two years ever since the
treatment.
But
the experts quickly warned that the treatment is not feasible for most AIDS
patients or HIV carriers because for one thing donors with the genetic mutation
that may be responsible for the miraculous cure are rare.
Only one in every 1,000 Europeans and
Americans may carry the desirable mutation.
Other
obstacles to successfully receiving the procedure are high risk of dying from
the procedures itself.
Studies showed
20 to 30 percent of patients die from bone marrow transplant because the sick
bone marrow needs to be killed by high doses of radiation and or medications.
Even
if some people can find a HIV-resistant donor and be able to survive the
procedure, bone marrow transplant is too costly for millions of HIV carriers
and AIDS patients who live in Africa where the disease is most commonly seen.
The
42-year-old man suffered both leukemia and HIV.
Ever since he received the transplant at
Berlin's Charite clinic two years ago, he had been free of HIV virus as tests
on the man's bone marrow, blood and other organ tissues had been all clear.
Scientists
believe the mutated gene of concern, called Delta 32, prevents HIV from
attaching itself to cells by blocking a receptor called CCR5.
But
doctors are not so sure if the man was cured because of the genetic mutation in
the donated bone marrow.
But
theoretically, knocking out the receptor by a gene therapy may be a future
treatment for AIDS, Professor Andrew Sewell, University of Cardiff, was cited
by BBC as saying.
This
German case is an exceptional, said a health observer. Previous reports showed
that bone marrow transplantation could be more likely to spread HIV than cure
AIDS. (by Sue Mueller)
Vitamin
C inhibits replication of HIV
S.
Harakeh and R. J. Jariwalla at Linus Pauling Institute of Science and Medicine
in Palo Alto, CA has done quite some research on the inhibitory effect of
vitamin C on HIV replication and found that this vitamin along with other
reducing agents may be used as a treatment to reduce the virus titer.
For more information, read Vitamin C inhibits replication of HIV
Why HIV vaccine fails
Dr. A. White of Duke University medical Center A published an article in the Sep 2, 2008 issue of Medical Hypotheses suggests that Merck's V520 is destined to fail to prevent HIV infection in a recent trial.
Trial sponsored by Merck and the US government showed that the vaccine did not prevent infection in those not previously infected with HIV, nor did the vaccine reduce the virus load in those who did receive the vaccine.
As a matter of fact, those who received the vaccine were actually much more likely to become HIV positive, particularly among men who were also uncircumcised and had pre-existing immunity to adenovirus type 5, which was used as a carrier for the vaccine.
Dr. White said vaccines prior to V520 were intended to evoke strong anti-body-mediated immune response to prevent HIV virus from entering host cells. V520 however was meant to evoke a cell-mediated immune response to HIV, allowing HIV entering cells and then trying to conquer it in the infected cells.
According to Dr. White, these two types immune response, antibody-mediated for extracellular infections and cell-mediated primarily for intracellular infections work in a teeter-totter manner. When one is suppressed the other is activated.
V520 was well intentioned, White said. HIV quickly infects host cells right after entering the body, and a strong cell-mediated response is required to defeat the HIV virus.
The problem, it seems to dr. White, is that the antibody-mediated immune response triggered by V520 suppressed the ability of the body to have the cell-mediated immune response that is needed to protect against HIV creating a window of opportunity for HIV infection. This is particularly the case for those who had exposed themselves to the adenovirus vector.
Dr. White acknowledged that the immune system uses antibodies to indentify extracellular pathogens, also said that it uses transfer factors to label infected host cells.
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