Caffeine cravings may be brewing in your genes
by Aimee Keenan-Greene
Are you a java junkie?
The need for a daily dose of Joe, diet soda, or energy drinks could be linked to your DNA, according to a new study in the journal PloS Genetics.
Caffeine is the most widely consumed psychoactive substance in the world, says scientists involved in the study.
Now for the first time a genome-wide association study of habitual caffeine intake reveals a 'large heritable component;.
Researchers included 47,341 people of European descent based on five population-based studies in the United States.
Through a comprehensive search of the human genome, scientists discovered two loci associated with habitual caffeine consumption: the first near AHR and the second betweenCYP1A1 and CYP1A2.
Both the AHR and CYP1A2 genes are biologically plausible candidates, as CYP1A2metabolizes caffeine and AHR regulates CYP1A2.
In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4×10−19), near AHR, and 15q24 (P = 5.2×10−14), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2.
Caffeine intake was assessed using semi-quantitative food frequency questionnaires (FFQ) that included questions on the consumption of caffeinated coffee, tea, soft drinks, and chocolate.
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