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Breast density, lobular involution linked to breast cancer risk

11/01/2010 11:56:00 admin

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The National Breast Cancer Awareness Month or the pink month is over. But we still need to be aware of the risk for breast cancer. We will continue publishing reports on the issue to help readers better understand the disease. Below is a new study report.

Women with dense breasts and no lobular involuton are at higher risk for developing breast cancer than those who do not have dense breasts and complete involution, a study in the National Cancer Institute suggests.

Mammographic breast density and extent of lobular involution are two known risk factors for breast cancer. Lobular involution is the physiological atrophy of the breast epithelium and its extent increases with increasing age.

For the study, Karthik Ghosh, M.D., of the Mayo Clinic, and colleagues determined the association of breast density, lobular involution and breast cancer risk in a cohort of 2,666 women with benign breast disease diagnosed between 1967 and the end of 1991.

These subjects were part of the larger Mayo Breast Disease cohort including 9,376 women aged 18 to 85 who did not have breast cancer at baseline. During the 13-year follow-up, 172 or 6.5 percent of the participants were diagnosed with breast cancer.

Ghosh et al. found breast density and extent of lobular involution were independent risk factors for breast cancer and when combined, they pose a greater risk.

They wrote "Our findings also reveal that having a combination of dense breasts and no lobular involution was associated with higher breast cancer risk than having non-dense or fatty breasts and complete involution."

Breast cancer is diagnosed in more than 175,000 women and the disease kills about 50,000 women each year in the United States, according to American Cancer Society. The disease is expected in one in seven women in their lifetime.

Many lifestyle parameters can be modified to reduce the risk of developing breast cancer. Foodconsumer.org has extensively reported on many recent studies on breast cancer risk, which may offer some hint as to how to prevent.

David Liu

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