Fat around the heart boosts heart attack risk (PR)

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studied by intravascular ultrasound

Topics: 

Basic Science

Date : 

28 Aug 2011

Paris, France, 28 August: 
Pericardial thickness was significantly correlated with coronary arterial remodeling and non calcified plaque - related to acute coronary syndrome (ACS) in a Japanese study presented at the ESC Congress 2011 by Dr Riyo Ogura today.

Recently, interest in the fat around the heart -so called pericardial fat- is rapidly growing. Even a thin person can have pericardial fat. Several studies suggest that pericardial fat induces inflammation of the artery wall by secretion of pro-inflammatory proteins and plays a role in the pathogenesis of coronary artery disease. However, there is no information regarding the impact of pericardial fat on coronary arterial remodeling and plaque vulnerability- related with acute coronary syndrome.

“The aim of our study was to evaluate the relationship between pericardial fat and intravascular ultrasound (IVUS) findings, mainly coronary remodeling, in patients with coronary artery disease,” said Dr Ogura.
One hundred and eight consecutive patients with de novo lesions located in native coronary artery were studied. The pericardial fat thickness on the right ventricle was measured using transthoracic echocardiography, and arterial remodeling of culprit lesion was assessed by pre-interventional IVUS. The remodeling index (RI) was calculated as lesion divided by the reference external elastic membrane cross-sectional area, Positive remodeling (PR) was defined as RI>1.05, intermediate remodeling (IR) as between 0.95 and 1.05, and negative remodeling (NR) as <0.95. IVUS findings included plaque eccentricity and morphology-lipid rich, fibrous and calcified.

There was a significant relationship between pericardial fat thickness and RI(r= 0.36, p=0.0001). Patients with a higher pericardial fat thickness (>10mm, n=55) were significantly associated with high body mass index (25.2±3.6kg/m² vs. 23.9±2.8 kg/m², p=0.04), high plasma triglyceride level (189.1±103.8mg/dl vs. 146.1±80.9 mg/dl, p=0.02) ,and high plasma urinary acid level(6.8±1.5mg/dl vs. 5.9±1.5 mg/dl, p=0.02). PR and  noncalcified plaque were more common in patients with a higher pericardial thickness (PR ;43.6% vs. 18.9%,p=0.02. non-calcified plaque; 89.1% vs.66.0%, p=0.004).

There was no significant relationship between pericardial fat thickness and plaque eccentricity. Multivariate analysis showed that high pericardial fat thickness was an independent factor affecting coronary positive remodeling (odds ratio (OR):3.05,p=0.02).

In conclusion, pericardial fat thickness was significantly correlated with the coronary arterial remodeling and non calcified plaque - related with acute coronary syndrome.

 

Authors:

Doctor Ogura, Riyo (Komatsushima, Japan)

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Notes to editor

 

About the European Society of Cardiology
The European Society of Cardiology (ESC) represents more than 68,000 cardiology professionals across Europe and the Mediterranean. Its mission is to reduce the burden of cardiovascular disease in Europe.

About ESC Congress 2011
ESC Congress 2011 will take place from 27 to 31 August at the Parc des Expositions - Paris Nord Villepinte, France. Information on the scientific programme is available here. More information on ESC Congress 2011 is available from the ESC Press Office or contact us at press@escardio.org

References

This press release accompanies both a presentation and an ESC press conference at the ESC Congress 2011. 

abstract number :84308, Relationship between epicardial adipose tissue and coronary arterial remodeling as assessed by intravascular ultrasound in patients with coronary artery disease

The press release has been written by the investigator and edited by the ESC and does not necessarily reflect the opinion of the European Society of Cardiology. 

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