Nickel carcinogenesis & Cobalt carcinogenesis

The exact mechanisms of nickel-induced carcinogenesis are not known and have been the subject of numerous epidemiologic and experimental investigations. High doses are best delivered into the cells by phagocytosis of sparingly soluble nickel-containing dust particles. Ultimately, the investigations of nickel carcinogenesis should be aimed at the development of treatments that would inhibit or prevent Ni(II) interactions with critical target molecules and ions, Fe(II) in particular, and thus avert the respiratory tract cancer and other adverse health effects in nickel workers. Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, 2003    http://www.ncbi.nlm.nih.gov/pubmed/14643413?dopt=Abstract&holding=f1000,f1000m,isrctn

Cobalt significantly increased the incidences of combined malignant and benign tumors at multiple tissue sites in experimental animals. It caused lung tumors in male and female mice and female rats, as well as adrenal gland tumors in the female rats. However, the mechanism by which cobalt ions induce cancer remains unclear. The results of this study will broaden our understanding on cobalt carcinogenesis. This study sheds light on the possible mechanisms involved in cobalt-induced alteration of histone modifications, which may lead to altered programs of gene expression and carcinogenesis since cobalt at higher concentrations is a known carcinogen. Qin Li, Qingdong Ke and Max Costa, 2008    http://carcin.oxfordjournals.org/content/30/7/1243.full

In my opinion, nickel and cobalt cancer researchers can open schoolbooks, make a discovery and receive Nobel Prizes   diamagnetic Gold Medals. Nickel, cobalt and iron are ferromagnetic materials and well-known carcinogens. California Institute of Technology and Oregon State University have detected the presence of ferromagnetic particles (contaminants) in the human cells.   http://www.tutuz.com/?p=1531
http://mydocs.epri.com/docs/public/TR-111901.pdf      

Cancer cell is normal cell   numerous crystalline ferromagnetic contaminants (Fe, Fe3O4, Co, Ni, etc.). Cellular location, ultrastructure, magnetomechanical effects and biological function of intracellular ferromagnetic particles, 1992, PNAS USA    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC49775/
Nickel and cobalt cancer researchers can research Iron Conception (Ferromagnetic theory-2006 of cancer) and cease “not known” and “unclear” researches.

By V. Shapoval & Tigran H.  http://www.tutuz.com   South Carolina, USA