Researchers Increase Longevity of Mice Genetically

By Rachel Howell Stockton

Research performed by the Healthy Aging University College in London is showing that gene manipulation can increase the longevity of mice.

Many scientists concur that a low calorie diet can lead to certain genetic changes that also increase longevity.  The production of a protein called S6K1 is halted when a person goes on a low calorie diet; it changes in response to a reduction of caloric intake.

In the study, however, the researchers were able to genetically block production of the protein without altering the food intake of the mice.  Several age related illness, such as Type 2 diabetes were circumvented and the life span of the mice was increased by 1/5.

There also seems to be an increase in the quality of life by halting the protein; the mice had improved motor skills and stronger bones.  Additionally, the T-cells of the manipulated mice were more “youthful;” stronger T-cells help to slow down the natural aging process associated with declining immunity. Quality of life is just as important as longevity, as it affects mental health and a person’s overall sense of well being.  We are not merely interested in prolonging our lives, but in making those additional years enjoyable by reducing illness.

Recently, scientists discovered that resveratrol, the anti-oxidant found in red wine, also helps to slow down the aging process by mimicking the biological changes that are manifested by lowering calorie intalke.

The London study is being reported in the journal Science.