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More evidence shows drinking coffee cut type 2 diabetes mellitus risk

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The effect of the timing of drinking coffee

Sartorelli D.S. and colleagues from University of São Paulo in Ribeirão Preto, Brazil reported in the April 2010 issue of American Journal of Clinical Nutrition that drinking more than one cup of coffee a day reduced the risk of diabetes by 27 percent in women, compared with those who did not drink.

The researchers followed 69,532 French women aged 41 to 72 years and found the inverse association was only found among those who drank coffee at lunchtime. Those drinking one cup of coffee a day at lunchtime cut their risk of diabetes by 33 percent, compared with those who did not drink.

The inverse association was observed both for regular and decaffeinated coffee and both black coffee and filtered coffee, but not for sweetened coffee.

Total caffeine was inversely associated with reduced risk of diabetes, but consumption of tea, which also contains caffeine, and chicory was not correlated with diabetes risk.

The researchers suggested that the timing of drinking coffee may play a role in the development of tyoe 2 diabetes.

Drinking four cups of coffee boosts production of SHBG

Researchers at University of California at Los Angeles found evidence that suggests caffeinated coffee reduces the risk of type 2 diabetes by increasing the serum level of a protein called sex hormone-binding globin or SHBG.

SHBG regulates the biological activity of the body's sex hormone, testosterone and estrogen and it's been known for long that it may play a role in the development of type 2 diabetes mellitus.

Dr. Simin Liu and colleagues reported in the journal Diabetes that women who drank four cups of coffee each day had higher amounts of SHBG than non-drinkers and were 56 percent less likely to be diagnosed with type 2 diabetes mellitus, compared with non-drinkers.

Further research showed coffee consumption also benefits the protective copy of the SHBG gene, on which two mutations are known to influence the production of SHBG, one increasing the output of the protein and the other suppressing the production.

Additionally, Liu et al. found decaffeinated coffee did not render any protection against type 2 diabetes mellitus.

The researchers reported their findings in the journal Diabetes.

David Liu and Stephen Lau

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