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Eating fructose leads to high plasma uric acid level

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By David Liu, PHD

Friday Aug 3, 2012 (foodconsumer.org) -- A new study released recently in Nutrition and Metabolism showed eating fructose for 10 weeks increased more fasting uric acid, a compound that causes a condition called gout,  in the blood than eating glucose.  Both fructose and glucose are present in high fructose syrup or now called corn sugar, which is commonly used in processed foods and sugar-sweetened beverages.

In the study led by CL Cox and colleagues, older, overweight and obese men and women with body mass index of 25 to 35 kg/m2 drank glucose or fructose-sweetened beverages for 10 weeks in such an amount that 25 percent of total energy came from the sugar in the beverage.

Consumption of fructose, but not glucose, was found to significantly increase 24-h uric acid profiles and RBP-4 concentrations, as well as plasma GGT activity.

Fasting plasma uric acid levels increased in both groups; but eating fructose raised the uric acid level to a higher level than eating glucose, the study found.

The researchers concluded "These findings suggest that consumption of fructose at 25% of energy requirements for 10 wks, compared with isocaloric consumption of glucose, may contribute to the development of components of the metabolic syndrome by increasing circulating uric acid, GGT activity, suggesting alteration of hepatic function, and the production of RBP-4."

An accumulation of sodium urate crystals in the joints can cause a medical condition called gout.

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