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Dietary supplement reduces cardiovascular damage induced by type 2 diabetes mellitus

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Thursday Nov 14, 2013 (foodconsumer.org) -- Taking a dietary supplement called Kalpaamruthaa helps prevent cardiovascular damage associated with type 2 diabetes mellitus, at least in experimental rats with cardiovascular damage, according to a new study recently published in Canadian Journal of Physiology and Pharmacology.

Cardiovascular disease is one of the most serious complications of type 2 diabetes mellitus.   Many diabetes mellitus die from heart disease.  For this reason, all Any measure that can be employed to prevent heart disease such as statin therapy may help patients with type 2 diabetes mellitus.

The study led by R. Latha from Post-Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus in Chennai,  India and colleagues also found that the protective effect of Kalpaamruthaa against cardiovascular damage which can be induced by type 2 diabetes mellitus was rendered by reducing oxidative stress and the modulation of the protein kinase C-β (PKC-β)/Akt signaling pathway, whose deregulation is also implicated in tumor progression, according to previous studies.

For the study, rats with induced cardiovascular damage were treated orally with 200 mg of Kalpaamruthaa per kg body weight per day for four weeks.

And the study shows that supplementation of Kalpaamruthaa effectively improved insulin resistance with alteration in blood sugar, hemoglobin, and glycosylated hemoglobin in the rats with induced cardiovascular disease.  The dietary supplement also decreased the elevated levels of lipids and normalized lipoprotein in the rats.
Kalpaamruthaa was also found to effectively increase the activities and or levels of enzymatic and nonenzymatic antioxidants and reduced the fatty inclusion and mast cell infiltration and the lipid peroxidative product and protein carbonyls in the liver of the rats.  Antioxidants help both diabetes mellitus and hear disease.

Additionally the supplement also reduced the chromatin condensation and improved insulin signaling by decreasing PKC-beta and increasing p-Akt and GLUT4 expression in the heart of the rats.

The researchers concluded "The above findings suggest that KA renders protection against CVD induced by type 2 diabetes mellitus by augmenting the cellular antioxidant defense capacity and modulating PKC-β and the p-Akt signaling pathway."
The same research team also conducted another study of rats with type 2 diabetes mellitus induced with Streptozotocin after being on a high fat diet for two weeks.  Cardiovascular disease developed eight weeks after type 2 diabetes mellitus was induced and confirmed the protective effect of Kalpaamruthaa against cardiovascular disease.

Quite some dietary supplements can be used to effectively prevent and or treat type 2 diabetes mellitus including spirulina, cinnamon, curcumin and bitter melon among others. (David Liu, PHD)

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