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Pectinase-treated ginseng radix improves hyperglycemia and hyperlipidemia in diabetes patients

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Saturday Oct 12, 2013 (foodconsumer.org) -- A new study in Biological Therapy suggests that taking pectinase treated ginseng radix can help type 2 diabetes mellitus patients who are on a high fat diet to lower their blood sugar and cholesterol.
H.  D. Yuan and from College of Pharmacy, Kyung Hee University in Seoul, Republic of Korea and colleagues conducted the study and found pectinase-treated red ginseng radix (ethanol extract) helped hypeglycemia and hyperpipidemia in mice on a high fat diet in a dose-responsive manner.

In the study, four groups of mice were treated with regular diet, or high fat diet, or high fat diet plus pectinase treated red ginseng extract at three doses including 75 mg/kg, 150 mg/kg and 300 mg/kg.

Oral glucose tolerance test showed that mice treated with red ginseng extract improved the glucose tolerance after the glucose challenge.   Fasting serum glucose and insulin levels were decreased up to 19.6% and 20.9% respectively in those using 300 mg of red ginseng extract per day. Insulin resistance indices were also decreased by 36.4% in mice using the highest dose of red ginseng extract, compared with controls.

In the group of mice using the highest dose of red ginseng extract also reduced the plasma triglyceride, total cholesterol and non-esterified fatty acid levels, compared with controls.

The supplementation of red ginseng extract in the highest dose also decreased the enlarged adipocytes and shrunken islets to a normal level.

The researchers concluded " In summary, GINST (Pectinase-Processed Ginseng Radix) prevents HFD (high fat diet)-induced hyperglycemia and hyperlipidemia through reducing insulin resistance via activating AMPK-GLUT4 pathways, and could be a potential therapeutic agent for type 2 diabetes."

Type 2 diabetes mellitus patients often use a high fat diet to minimize intake of carbohydrates.  The high fat diet itself can cause health problems when used for a long term. (DL)

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