Subclinical Vitamin K Deficiency boosts Knee Osteoarthritis risk

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By Jimmy Downs

SSunday March 3, 2013 (foodconsumer.org) -- ubclinical vitamin K deficiency may increase risk of knee osteoarthritis, according to a new study recently published in the American Journal of Medicine.

Devyani Misra, MD, MS from Boston University School of Medicine in Boston, Mass and colleagues conducted the study and found men and women who had subclinical vitamin D deficiency were 56 percent more likely to develop knee osteoarthritis, compared with those who had no deficiency.

Osteoarthritis is the most common arthritis and knee osteoarthritis is the leading cause of lower extremity disability among older Americans.  There is no treatment available to prevent osteoarthritis.

Vitamin K is known to play a role in regulating skeletal mineralization and therefore may be involved in the pathology of osteoarthritis. The current study was intended to examine the association between subclcinical vitamin D deficiency and risk of knee osteoarthritis.

Participants enrolled in the Multicenter Osteoarthritis (MOST) Study were subject to knee radiographs and MRI scans at baseline and 30 months later and serum phylloquinone (vitamin K) was measured at baseline.

Participants with subclinical vitamin K deficiency was found associated with 56 percent increased risk of incident radiographic knee osteoarthritis and 139 percent increased risk of cartilage lesions, compared with those without vitamin D deficiency.

The researchers concluded "In the first such longitudinal study, subclinical vitamin K deficiency was associated with increased risk of developing radiographic knee osteoarthritis and MRI-based cartilage lesions."

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