foodconsumer.org: Mango fights cancer

Mango fights cancer
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admin on 03/13/2010 15:12:00
 
One study reported earlier on foodconsumer.org shows papaya extracts may help
fight cancer. Now another study in the March 5 2010 issue of Journal of
Agricultural and Food Chemistry suggests that mango may also do the same thing.
Noratto G.D. and colleagues from Department of Nutritionn and Food Science at
Texas A&M University in College Station Texas tested anticancer activity of
polyphenolic extracts from several mango varieties including Francis, Kent,
Ataulfo, Tommy Atkins and Haden in cancer cell lines including Molt-4 leukemia,
A-549 lung, MDA-MB-231 breast, LnCap prostate and SW-480 colon cancer cells and
the non-cancer colon cell line CCD-18Co.
The researchers found Ataulfo and Haden extracts had higher anticancer activity
than other varieties Kent, Francis, and Tommy Atkins.  Ataulfo at 5 mg of GAE/L
inhibited the growth of colon SW-480 cancer cells by about 72 percent while it
did not inhibit the noncancer colon cells.
They also found Ataulfo and Haden polyphenolics exerted their anticancer
activityy against colon SW-480 cancer cells by increasing mRNAexpressionon of
pro-apoptotic biomarkers and cell cycle regulators, cell cycle arrest and
reducing reactive oxygen species.
By David Liu