foodconsumer.org: Vitamin C cuts smoking-induced atherosclerosis risk

Vitamin C cuts smoking-induced atherosclerosis risk
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admin on 05/15/2010 19:16:00
 
Smoking cigarettes increases risk of atherosclerosis, but vitamin C
supplementation may help offset the effect, according to a new study.
The study led by Ray T and colleagues from the University of Calcutta was meant
to examine the effect of a diet supplemented with vitamin C on the development
of atherosclerosis in an animal model.
For the study, Ray et al fed  guinea pigs a diet with or without vitamin C
supplemented and observed apoptosis, which is believed to promote progression of
atherosclerosis, in cigarette smoke-exposed guinea pig aorta.
The researchers further discovered that the apoptosis in aortal sections is
mediated at least partially by an increased Bax/Bc12 ratio.
However, atherogenic changes were rarely observed in guinea pigs fed with
vitamin C supplemented diet.
Ray et al explained that vitamin C protects against atherosclerotic activity
partly by inhibiting cigarette-smoking induced apoptosis and platelet
activation.
They concluded that "Exposure of guinea pigs to cigarette smoke causes the
development of atherosclerosis, which can be prevented by vitamin C supplement."
The study was published in the May 13, 2010 issue of Journal of Atherosclerosis
and Thrombosis.
David Liu