Diesel motor exhaust boosts lung cancer risk
Exposure to diesel motor exhaust increases risk of lung cancer, a study published in American Journal of Respiratory and Critical Care Medicine suggests.
The study meta-analysed data from case-control studies and found those who had greatest cumulative exposure to diesel exhaust were up to 31 percent more likely to be diagnosed with lung cancer compared to those who had the lowest exposure.
Authors of the study Olsson A.C. at Karolinska Institutet and colleagues said in their report that diesel motor exhaust is classified by the International Agency for Research on Cancer as probably human carcinogen.
Olsson's analysis was based on data from 11 case-control studies conducted in Europe and Canada of 13,304 lung cancer cases and 16,282 controls on the association between occupational exposure to diesel motor exhaust and risk of lung cancer.
High occupational exposure was found to boost the risk of lung cancer by as much as 31 percent and the association was derived from an analysis after adjustment for confounders like age, sex, ever employment in an occupation with established lung cancer risk, cigarette smoking.
Olsson et al. said similar effects were also found in workers who were never employed in risky-occupations, in women and never-smokers although the associations were not statistically significant.
The researchers wrote "Our results show a consistent association between occupational exposure to diesel motor exhaust and increased risk of lung cancer. This association is unlikely explained by bias or confounding, which we addressed by adjusted models and sub-group analyses.
Another study recently released found type 2 diabetes drug metformin ad other diabetes drugs may slow the progression of lung cancer and extend survival.
The study was conducted by Peter J. Mazzone, MD and presented at CHEST 2010, the annual meeting of the American College of Chest Physicians in Canada.