> ## Content Index > Fetch the complete content index at: https://www.foodconsumer.org/llms.txt > Use this file to discover other available public pages before exploring further. # B vitamins help Alzheimer's disease - URL: https://www.foodconsumer.org/b_vitamins_help_alzheimer_s_disease_0926160929/ - Published: 2016-09-26T12:26:00.000Z - Updated: 2026-09-15T11:45:49.000Z - Description: In a study led by David Smith at Oxford, B vitamins helped preserve memory and cognition in early-stage Alzheimer's patients only when omega-3 levels were high: among those, a third worsened over two years versus 59 percent on placebo. B vitamins did not help when omega-3 levels were low. - Author: Food Consumer - Tags: Nutrition, #vivvo-import Sept 26, 2016 (foodconsumer.org) -- David Smith at University of Oxford in Oxford, United Kingdom and colleagues released a study to suggest that taking B vitamins may help prevent brain atrophy and cognitive decline in early stage Alzheimer's disease. An early study of people with mild cognitive impairment has already indicated that B vitamin supplementation intended to help lower homocysteine could actually slow the rate of brain atrophy and cognitive decline. The study led by Smith et al. shows that supplementation with B vitamins helped maintain episodic memory, global cognition and clinical dementia rating (CDR) sum-of-boxes better in people with early stage Alzheimer's disease with high serum concentrations of omega 3 - fatty acids. Specifically, among patients with good omega-3 status, one third of those on B vitamin supplementation had global CDR scores greater than 0 (i.e., got worse) after two years compared with 59% among those treated with placebo. The study also finds that in patients with early stage Alzheimer's disease, B vitamin supplementation did not help when concentrations of omega-3 fatty acids were low, and omega 3 fatty acid docosahexaenoic acid (DHA) was more effective than eicosapentaenoic acid (EPA) at maintaining episodic memory, global cognition and CDR sum-of-boxes. For the study, 266 patients with mild cognitive impairment or early stage Alzheimer’s disease aged ≥70 years who were randomized to B vitamins (folic acid, vitamins B6 and B12) or placebo for two years. The authors conducted another study early and found that B vitamins helped slow brain atrophy in patients with a good baseline omega 3 fatty acid status. This and other studies suggest that combinational supplementation of omega-3 fatty acids and B vitamins may help prevent progression of early stage Alzheimer's disease or mild cognitive impairment. (David Liu) *[David Smith, Helga Refsum, Abderrahim Oulhaj, Celeste A de Jager and Fredrik Jerneren, Beneficial Interactions Between B Vitamins and Omega-3 Fatty Acids in the Prevention of Brain Atrophy and of Cognitive Decline in Early Stage Alzheimer’s Disease, April 2016 The FASEB Journal, vol. 30 no. 1 Supplement 407.6](http://www.fasebj.org/content/30/1%5FSupplement/407.6.short?ref=foodconsumer.org)* **Similar report on Alzheimer's disease and dietary supplements** ### [Turmeric, curcumin fights Alzheimer's disease](https://www.foodconsumer.org/turmeric%5Fcurcumin%5Ffights%5Falzheimer%5Fs%5Fdisease%5F0605141128/) www.foodconsumer.org/.../turmeric\_curcumin\_fights\_**alzheimer**\_s\_disease... Jun 5, 2014 - Thursday June 5, 2014 (foodconsumer.org) -- Doctors say that there is no cure for Alzheimer's disease. 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