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# Want live longer? Take beta-hydroxybutyrate!
- URL: https://www.foodconsumer.org/beta-hydroxybutyrate_0817141150/
- Published: 2014-08-18T00:49:00.000Z
- Updated: 2026-09-22T16:10:23.000Z
- Description: Beta-hydroxybutyrate extended the lifespan of the roundworm C. elegans by 20 percent, raised heat tolerance, partly prevented glucose toxicity, and delayed amyloid beta toxicity and alpha-synuclein aggregation. The authors link the effect to conserved stress-response pathways.
- Author: Food Consumer
- Tags: Supplements, Nutrition, #vivvo-import

Sunday Aug 17, 2014 (foodconsumer.org) -- Calorie restriction is known to extend your lifespan. But for most people, it is hard to follow a calorie restricted diet for a long term. Thus drugs and or supplements that can have the same lifespan-extending effect are highly desired.

A new study published this month suggests that beta-hydroxybutyrate may extend lifespan drastically. The supplement was tested in a type of roundworm (C. elegans) and found able to extended the lifespan of the low animal by 20%.

Beta-hydroxybutyrate supplementation also increased thermtolerance in the worm and partially prevented glucose toxicity. Additionally, it delayed Alzheimer's amyloid beta toxicity and reduced Parkinson's alpha-synuclein aggregation.

The study also finds evidence indicating that the life-extending effect of beta-hydroxybutyrate is realized through the activation of conserved stress response pathways.

Beta-hydroxybutyrate or beta-hydroxybutyric acid is a histone deacetylase inhibitor and has been shown to be protective against many diseases. (David Liu, PHD)

Edwards C, Canfield J, Copes N, Rehan M, Lipps D, Bradshaw PC. D-beta-hydroxybutyrate extends lifespan in C. elegans. Aging (Albany NY). 2014 Aug 7.