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# Black seed, garlic  help fructose induced metabolic syndrome
- URL: https://www.foodconsumer.org/black_seed_garlic_help_fructose_induced_metabolic_syndrome_08071/
- Published: 2014-08-07T15:48:00.000Z
- Updated: 2026-09-22T16:29:47.000Z
- Description: In rats fed a high-fructose diet, supplements of black seed or garlic, alone or together, largely restored the weight, cholesterol, triglyceride and liver enzyme changes the diet caused, King Saud University researchers report in the Journal of Oleo Science.
- Author: Food Consumer
- Tags: Supplements, Nutrition, #vivvo-import

Thursday Aug 7, 2014 (foodconsumer.org) -- Researchers at King Saud University have recently published a study in Journal of Oleo Science suggesting that black seed (Nigella sativa, NS) and garlic (Allium sativum) supplementation may be used to treat fructose-induced metabolic syndrome (MS).

In the study, male rats in five groups received one of the five treatments, normal chow/tap water, normal chow/tap water with 10% fructose, high fructose diet with black seed, high fructose diet with garlic, and high fructose diet with both garlic and black seed supplements for weight weeks.

The high fructose diet without black seed, garlic supplementation significantly decreased high density lipoprotein cholesterol, activities of enzymes including Lactate dehydrogenase (LDH), glucose -6-phosphate dehydrogenase (G-6-PHD) and catalase in liver tissues.

At the same time, the high fructose diet significantly increased body weight, liver weight, serum triglycerides, total cholesterol, fasting blood sugar, and low density lipoprotein cholesterol.

Supplementation with either black seed or garlic alone ir in combination more or less restored the altered metabolic parameters. Black seed and garlic supplementation reduced serum LDL-C and triglycerides and could normalize the activities of the enzymes in the liver.

The study concluded "both NS and garlic were effective in attenuating multiple abnormalities of MS (metabolic syndrome). Combination of these medicinal plants may have additional effectiveness in reducing serum TC, LDL-C and increasing HDL-C levels which could be a step in the prevention and management of MS." (David Liu)

Al-Rasheed N1, Al-Rasheed N, Bassiouni Y, Faddah L, Mohamad AM. Potential protective effects of nigella sativa and allium sativum against fructose-induced metabolic syndrome in rats. J Oleo Sci. 2014;63(8):839-48\.