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# Chlorogenic acid rich coffee helps insulin resistance
- URL: https://www.foodconsumer.org/chlorogenic_acid_insulin_resistance_0618140200/
- Published: 2014-06-18T14:59:00.000Z
- Updated: 2026-09-22T16:16:04.000Z
- Description: Ten healthy volunteers drank caffeinated or decaffeinated coffee high in chlorogenic acid, or ordinary decaf, for 14 days while overfed fructose. All three coffees lowered hepatic glucose production, but none significantly changed the liver fat that fructose overfeeding had more than doubled.
- Author: Food Consumer
- Tags: Phytochemicals, Nutrition, #vivvo-import

Wednesday June 18, 2014 (foodconsumer.org) -- Epidemiologic and experimental studies shown that chlorogenic acid, a polyphenol found in green coffee beans and also commercial coffee prevents diet-induced hepatic steatosis and insulin resistance, according to a report in American Journal of Clinical Nutrition.

The study did not test green coffee bean extract, but a chlorogenic acid rich coffee to examine its effect on the results of short term fructose overfeeding which is known to increase intrahepatocellular lipids and blood triglycerides and decrease insulin sensitivity in the liver of healthy humans.

In the study, 10 healthy subjects were given one of three dietary treatments for 14 days, caffeinated coffee high in chlorogenic acid, decaffeinated coffee high in chlorogenic acid and decaffeinated coffee with regular levels of chlorogenic acid. 

During the last six days of the intervention, a weight maintenance diet was supplemented with four grams of fructose per kg body weight per day and all participants were then also studied without coffee supplementation, but with or without four grams of fructose per kg body weight per day.

Compared to the control diet, the high fructose diet increased intrahepatocellular lipids by 102% and hepatic glucose production by 16% and decreased fasting lipid oxidation by 100%.

All three coffees decreased hepatic glucose production, but did not change intrahepatocellular lipids significantly.

The study concluded "Coffee consumption attenuates hepatic insulin resistance but not the increase of IHCLs induced by fructose overfeeding."

*Virgile Lecoultre, Guillaume Carrel, Léonie Egli, Christophe Binnert, Andreas Boss, Erin L MacMillan, Roland Kreis, Chris Boesch, Christian Darimont, and Luc Tappy Coffee consumption attenuates short-term fructose-induced liver insulin resistance in healthy men, The American Journal of Clinical Nutrition, March 2014.*

The protective effect of coffee against insulin resistance has been observed in previous studies which show that coffee or many of its components may be used as a dietary supplement to prevent type 2 diabetes mellitus.

The study published in the March, 2014 issue of Genes & Nutrition found coffee intake mitigated insulin resistance by decreasing serum glucose levels during an insulin tolerance test and also inflammation.

The study suggests "These results provide scientific insight on the probable positive effects of coffee intake on impaired insulin signaling; inflammation and obesity, thereby providing a new perspective on the prevention of obesity and T2D (type 2 diabetes mellitus)."

Chlorogenic acid has been known as a weight loss agent. Chlorogenic acids have been found by Japanese scientists to be able to inhibit the enzymatic activity of pancreatic lipase, which is needed for dietary fat absorption and metabolism. (David Liu, PHD)

*Huijuan Jia, Wanping Aw, Kenji Egashira, Shoko Takahashi, Shinya Aoyama, Kenji Saito, Yoshimi Kishimoto, Hisanori Kato, Coffee intake mitigated inflammation and obesity-induced insulin resistance in skeletal muscle of high-fat diet-induced obese mice, Genes & Nutrition, March 2014*