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# Curcumin may ease "side effects" of high fat diet
- URL: https://www.foodconsumer.org/curcumin_high_fat_diet_0526140213/
- Published: 2014-05-26T15:12:00.000Z
- Updated: 2026-09-22T16:24:19.000Z
- Description: In LDL receptor-deficient mice, curcumin at 500 to 1,500 mg per kg of diet cut uptake of oxidized LDL, slowed weight and body fat gain and, at the high dose, suppressed steatohepatosis and reduced fibrotic liver tissue, Tufts researchers report in Atherosclerosis.
- Author: Food Consumer
- Tags: Supplements, Nutrition, #vivvo-import

Taking curcumin as a dietary supplement may reduce the risk of atherosclerosis, fatty liver, and dyslipidemia associated with use of high fat diet, which may lead to the development of a range of chronic diseases such as heart disease and type 2 diabetes among other things. M. Meydani at Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University in Boston MA and colleagues conducted the study and found curcumin reduced uptake of oxidized low density lipoprotein (LDL) cholesterol in vitro indicating that it can lower cholesterol which is associated with atherosclerosis. Supplementation with curcumin also reduced body weight gain and body fat. Curcumin at a high dose also "suppressed development of steatohepatosis, reduced fibrotic tissue, and preserved glycogen levels in liver." The doses of curcumin used in the study ranged from 500 to 1500 mg per kg of diet. (David Liu PHD)

Reference

S.T. Hasan, J.-M. Zingg, P. Kwan, T. Noble, D. Smith, M. Meydani, Curcumin modulation of high fat diet-induced atherosclerosis and steatohepatosis in LDL receptor deficient mice, Atherosclerosis, Volume 232, Issue 1, Pages 40–51, January 2014