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# Dietary antioxidants fight esophageal cancer
- URL: https://www.foodconsumer.org/dietary-antioxidants-fight-esophageal-cancer/
- Published: 2008-06-02T13:33:00.000Z
- Updated: 2026-09-22T15:57:53.000Z
- Description: In a case-control study, Kubo and colleagues found people with the highest dietary vitamin E intake were 75 percent less likely to have Barrett's esophagus, and top vitamin C and beta-carotene consumers 52 percent less likely. Antioxidant supplements showed no such association.
- Author: Food Consumer
- Tags: Food, Nutrition, #vivvo-import

In the case-control study, the researchers compared 296 cases of Barrett's esophagus (BE), a potential precursor to esophageal cancer, 308 cases of gastroesophageal reflux disease and 309 controls.Intake of total and dietary antioxidants and fruits and vegetables was estimated for each subject based on the results from a validated 110-item food frequency questionnaire.Intake of dietary vitamin C and beta-carotene was inversely associated with the risk of Barrett's esophagus. Those who were in the quintile of the highest consumption of vitamin C and beta-carotene were 52 percent less likely to have BE than those in the lowest quintile.The strongest inverse association was found for vitamin E. Those who had the highest intake of vitamin E were 75 percent less likely to have Barrett's esophagus.Intake of fruits and vegetables was also inversely associated with the risk of BE. But intake of antioxidant supplements did not influence the risk of Barrett's esophagus.Antioxidants and fruits and vegetables were inversely associated with a GERD diagnosis, according to the researchers.Kubo and colleagues concluded "Dietary antioxidants, fruits, and vegetables are inversely associated with the risk of BE, while no association was observed for supplement intake. Our results suggest that fruits and vegetables themselves or associated undetected confounders may influence early events in the carcinogenesis of esophageal adenocarcinoma."Source:Am J Gastroenterol. 2008 May 20.Dietary Antioxidants, Fruits, and Vegetables and the Risk of Barrett's Esophagus.Kubo A, Levin TR, Block G, Rumore GJ, Quesenberry Jr CP, Buffler P, Corley DA.Division of Research, Kaiser Permanente, Oakland, California, USA.

Wirtten By David Liu, and edited by Heather Kelley.