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# Eating sugar increases breast cancer risk
- URL: https://www.foodconsumer.org/eating_sugar_increases_breast_cancer_risk_0204160948/
- Published: 2016-02-04T22:47:00.000Z
- Updated: 2026-09-15T14:36:56.000Z
- Description: A Cancer Research report finds sucrose raised breast cancer and lung metastasis risk in part by increasing 12-lipoxygenase, which produces 12-HETE, a metabolite found at high levels in breast tumors. Fructose, half of sucrose, accounted for the metastasis and the 12-HETE production.
- Author: Food Consumer
- Tags: Cancer, Avoiding Illness, #vivvo-import

Thursday Feb 4, 2016 (foodconsumer.org) -- Eating sugar increases risk of breast cancer and its lung metastasis, according to a new report in Cancer Research.The study finds that sucrose or sugar increases risk of breast cancer by increasing the production of 12-lipoxygenase, which catalyzes oxidation of arachidonic acid into 12-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12-HETE), a metabolite found high in breast cancer mass. Specifically, fructose which accounts for 50% of sucrose (the remaining 40% is glucose) was found to be responsible for lung metastasis and 12-HETE production. The study seems to suggest that breast cancer patients should avoid eating sucrose or sugar. (David Liu)*Yan Jiang, Yong Pan, Patrea R. Rhea, Lin Tan, Mihai Gagea, Lorenzo Cohen, Susan M. Fischer, and Peiying Yang, A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway, Cancer Res January 1, 2016 76; 24*