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# GABA fights fluoride induced hypothyroidism
- URL: https://www.foodconsumer.org/gaba-fights-fluoride-induced-hypothyroidism/
- Published: 2016-03-01T16:01:00.000Z
- Updated: 2026-09-22T16:28:00.000Z
- Description: Male mice given subacute sodium fluoride injections showed lower T4, T3 and thyroid hormone-binding globulin plus abnormal thyroid follicles. Mice also treated with GABA showed less metabolic toxicity and largely normalized thyroid structure, in what the authors call a first.
- Author: Food Consumer
- Tags: Supplements, Nutrition, #vivvo-import

Tuesday March 1, 2016 (foodconsumer.org) -- Fluoride is known to lower IQ in children, cause hypothyroidism, and increase risk of bone cancer and skeletal/dental fluorosis. A new study has for the first time found that a γ-aminobutyric acid (GABA), a common supplement, may help ameliorate the toxicity of fluoride and help hypothyroidism.

For the study, male mice were subject to subacute injection of sodium fluoride and these mice without being treated with GABA were found to have lower serum T4, T3 and thyroid hormone-binding globulin. Fluoride exposure also led to structural abnormalities in thyroid follicles.

When fluoride-exposed mice were treated with GABA, the metabolic toxicity of fluoride was decreased and the microstructure and ultrastructure of the thyroid gland was largely normalized. In the treated mice, the thyroid-stimulating hormone level was increased and the inhibitory effect was enhanced against apoptosis in thyroid follicular epithelial cells.

Fluoride is commonly added in public drinking water systems in hopes that this practice (fluoridation) can help lower the risk of dental caries even though a growing body of evidence has suggested fluoride does not really cut the risk while over-exposure to this toxic chemical is known to raise the risk of skeletal fluorosis and dental fluorosis, and lower IQ in children. GABA may hypothyroidism. Other remedies that protect against the toxicity of fluoride are also available. (David Liu)

*Haoyue Yang, Ronge Xing, , Song Liu, Huahua Yu, Pengcheng Li, γ-Aminobutyric acid ameliorates fluoride-induced hypothyroidism in male Kunming mice, Life Sciences, Volume 146, 1 February 2016, Pages 1–7*