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# Genotocity of metal nanoparticles: Animal studies
- URL: https://www.foodconsumer.org/genotocity_of_metal_nanoparticles_0718120824/
- Published: 2012-07-17T21:22:00.000Z
- Updated: 2026-09-22T16:18:03.000Z
- Description: Reviewing animal studies for Arh Hig Rada Toksikol, Austrian researchers report some nanoparticles cause DNA strand breaks and chromosomal damage, with genotoxicity depending on particle size, surface modification, exposure route and duration. They urge caution, saying the evidence is limited.
- Author: Food Consumer
- Tags: Chemical, Food Safety, #vivvo-import

By David Liu, PHD

Tuesday July 18, 2012 (foodconsumer.org) -- K Klien and J Godni?-Cvar of Medical University of Vienna in Vienna, Austria reviewed animal studies on the genotixicity of nanoparticles and found that some nanoparticles cause both DNA strand breaks and chromosomal damage in experiemntal animals.

The authors' review was published in the June 1, 2012 issue of Arh. Hig. Rada Toksikol.

The authors said vitro studies although inconsistent as always indicate that nanoparticles potentially cause DNA damage. Their review focused on in-vivo studies.

After reviewing relevant studies, the authors found the genotoxicity of nanoparticle depend not only on particle size, surface modification, and exposure route, but also on exposure duration.

Because evidence of toxicological and genotoxicological effects of nanoparticles is limited, the authors said caution should be exercised when potential exposure of humans to nanoparticles occurs.

Many studies although not all have found that nanoparticles can disrupt DNA and potentially cause genotoxicity in animals and humans exposed to the particles. Once getting into the body, nanaoparticles can find a way to migrate to organs like the liver, kidneys and brain.

Nanoparticles including titanium dioxide, silicon dioxide, iron oxide and zinc oxide are commonly used in processed foods, dietary supplements and personal care products.