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# High-Fat Diet Boosts Brain Proteins Linked to Alzheimer's Disease
- URL: https://www.foodconsumer.org/high_fat_diet_alzheimer_s_disease_0622130819/
- Published: 2013-06-22T21:18:00.000Z
- Updated: 2026-09-15T13:56:58.000Z
- Description: University of Washington researchers assigned 47 older adults, some with mild cognitive impairment, to a high-fat, high-glycemic-index diet or a low-fat, low-GI one. Within four weeks the high-fat diet raised lipid-depleted amyloid-beta, while the low-fat diet had the opposite effect.
- Author: Food Consumer
- Tags: Diet, Nutrition, #vivvo-import

A high-fat, high-glycemic-index diet increases the concentration of proteins in the brain that are linked to Alzheimer’s disease, according to a new study published by the American Medical Association. Researchers at the University of Washington assigned 47 older adults, some of whom already had mild cognitive impairment, to either a high-fat, high-GI diet or a low-fat, low-GI diet. Within four weeks, the high-fat diet increased the production of *lipid-depleted Aβ*, a protein linked to Alzheimer’s risk. The low-fat diet had the opposite effect. An accompanying commentary in the journal supports the finding that dietary choices can affect brain chemistry quickly and effectively.

Hanson AJ, Bayer-Carter JL, Green PS, et al. Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides. *JAMA Neurol*. Published ahead of print June 17, 2013.  

Blacker D. Food for thought. *JAMA Neurol*. Published ahead of print June 17, 2013.

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