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# Epstein-Barr virus, HPV linked to invasive breast cancer
- URL: https://www.foodconsumer.org/hpv_linked_to_invasive_breast_cancer_0601160424/
- Published: 2016-06-01T17:12:00.000Z
- Updated: 2026-09-15T14:38:42.000Z
- Description: Of 108 breast cancer samples from Syrian patients, 32% carried both Epstein-Barr virus and high-risk HPV, and that combination was associated with high-grade invasive tumors. Samples carrying only one virus were usually lower-grade ductal carcinomas.
- Author: Food Consumer
- Tags: Disease, Health News, #vivvo-import

Wednesday June 1, 2016 (foodconsumer.org) -- Co-presence of Epstein-Barr virus (EBV) and high-risk human papillomaviruses (HPVs) types 16, 18, 31, 33 and 35 could drastically increase risk for high grade invasive breast cancer, according to a new study led by A. E. Al Moustafa at Syrian Research Cancer Centre of the Syrian Society against Cancer in Aleppo , Syria and colleagues.Al Moustafa et al. have previously found Epstein-Barr virus (EBV) and high-risk human papillomaviruses (HPVs) types 16, 18, 31, 33 and 35 present in human breast cancer diagnosed in Syrian men and women.The new study found 32% of 108 breast cancer samples were positive for both EBV and high-risk HPVs and co-presence of the two viruses was associated with high grade invasive breast cancer. In comparison, breast cancer found with only one type of virus was often low to intermediate grade tumors (ductal carcinomas).These studies suggest that women infected with both Epstein-Barr virus (EBV) and high-risk human papillomaviruses (HPVs) types 16, 18, 31, 33 and 35 could be at high risk for high grade invasive breast cancer and these viruses are risk factors for metastasis.Many viruses including some [sexually transmitted viruses](http://www.theguardian.com/society/2016/jan/29/sexually-transmitted-virus-strongly-linked-to-risk-of-breast-cancer-study?ref=foodconsumer.org) have been associated with increased risk for a variety of cancers including breast cancer and leukemia. (David Liu)*Al Moustafa AE, Al-Antary N, Aboulkassim T, Akil N, Batist G, Yasmeen A. Co-prevalence of Epstein-Barr virus and high-risk human papillomaviruses in Syrian women with breast cancer. Hum Vaccin Immunother. 2016 Apr 15:1-4.* **Simialr studies**

[Incidence of Epstein-Barr virus in Syrian women with breast cancer: A tissue microarray study.](https://www.ncbi.nlm.nih.gov/pubmed/25933186?ref=foodconsumer.org)

[High-risk human papillomavirus infections in breast cancer in Syrian women and their association with Id-1 expression: a tissue microarray study.](https://www.ncbi.nlm.nih.gov/pubmed/18648363?ref=foodconsumer.org)

[Epstein-Barr virus, human papillomavirus and mouse mammary tumour virus as multiple viruses in breast cancer.](https://www.ncbi.nlm.nih.gov/pubmed/23183846?ref=foodconsumer.org)

[Review High-Risk HPVs and Human Carcinomas in the Syrian Population.](https://www.ncbi.nlm.nih.gov/pubmed/24765613?ref=foodconsumer.org)

[Review Epstein-Barr virus and breast cancer: state of the evidence for viral carcinogenesis.](https://www.ncbi.nlm.nih.gov/pubmed/15159298?ref=foodconsumer.org)