> ## Content Index
> Fetch the complete content index at: https://www.foodconsumer.org/llms.txt
> Use this file to discover other available public pages before exploring further.

# Indole-3-carbinol helps prevent cervical cancer
- URL: https://www.foodconsumer.org/indole-3-carbinol_helps_prevent_cervical_cancer_1304130819/
- Published: 2013-11-04T21:16:00.000Z
- Updated: 2026-09-22T16:28:52.000Z
- Description: In transgenic mice prone to cervical cancer under chronic estrogen exposure, 19 of 25 on a control diet developed cervical-vaginal cancer versus 2 of 24 fed a diet with 0.2% indole-3-carbinol, a compound in cruciferous vegetables, according to a study in Cancer Research.
- Author: Food Consumer
- Tags: Supplements, Nutrition, #vivvo-import

Monday Nov 4, 2013 (foodconsumer.org) -- Indole-3-carbinol a compound found in Cruciferous vegetables may help reduce the risk of cervical cancer and other reproductive cancers, according to a study in Cancer Research.

Liang Jin from The Long Island Campus of Albert Einstein College of Medicine in New Hyde Park, New York and colleagues conducted the animal study and found transgenic mice eating a diet supplemented with indole-3-carbinol were much less likely to develop cervical cancer, compared with controls.

For the study, transgenic mice that were prone to developing cervical cancer when chronically exposed to estrogen were fed a diet supplemented with 0.2% of indole-3-carbinol (w/w) or a control diet while exposed to 0.125 mg of 17β-estradiol for 60 days.

During the 6-month follow-up, 19 of 25 transgenic mice developed cervical-vaginal cancer and the remainder acquired dysplasia. In contrast, only 2 of 24 mice on the diet supplemented with indole-3-carbinol developed cervical-vaginal cancer and the remainder suffered dysplasia or hyperplasia.

In wild-type mice, indole-3-carbinol was found able to lower the risk dysplasia. 

In mice exposed to a high dose of estradiol (0.25 mg per 60 days), similar results were observed. And at the higher dose of estradiol, indole-3-carbinol helped to prevent morbidity.

Additionally, indole-3-carbinol helped reduce the risk of skin cancer in transgenic mice.

Indole-3-carbinol is available as a dietray supplement and can be purchased on the Internet or local health stores. (David Liu)