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# Mice Fail as Models of Human Inflammation: National Academy of Sciences
- URL: https://www.foodconsumer.org/inflammation_0213130659/
- Published: 2013-02-13T19:58:00.000Z
- Updated: 2026-09-15T13:52:09.000Z
- Description: A PNAS study comparing genomic responses in patients with severe trauma, burns and sepsis concluded that human inflammatory responses are not reproduced in current mouse models, which the authors say may explain why over 150 drugs that worked in mice failed in sepsis patients.
- Author: Food Consumer
- Tags: Drug, Health News, #vivvo-import

Studies of inflammatory diseases in mice have been misleading researchers for years, according to a new study just published in the *Proceedings of the National Academy of Sciences*. The researchers analyzed data obtained from human patients who had suffered severe blunt trauma, burns, and sepsis (the body’s severe response to infection) and other inflammatory diseases. They found that the way in which humans respond to inflammation is “not reproduced in the current mouse models.” This could explain why more than 150 drugs that were tested in mice failed in patients with sepsis. The study’s authors concluded: “New approaches need to be explored to improve the ways that human diseases are studied.”

Seok J, Warren HS, Cuencac AG, et al. Genomic responses in mouse models poorly mimic human inflammatory disease. *PNAS*. Published online before print February 11,2013.

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