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# Insulin therapy for type 2 diabetes mellitus can cause type 1 diabetes mellitus
- URL: https://www.foodconsumer.org/insulin_therapy_0628141047/
- Published: 2014-06-28T23:46:00.000Z
- Updated: 2026-09-22T16:01:52.000Z
- Description: A Japanese study of six type 2 diabetes patients, averaging 59.5 years, found glucose control deteriorated and C-peptide dropped to insulin-deficient levels an average 7.7 months after insulin therapy began. All carried high-risk HLA class II and insulin gene VNTR genotypes.
- Author: Food Consumer
- Tags: Disease, Health News, #vivvo-import

Saturday June 28, 2014 (foodconsumer.org) -- Patients with type 2 diabetes mellitus being treated with insulin may develop type 1 diabetes mellitus, a new Japanese study suggests.

The study analyzed data from six patients with insulin triggered type 1 diabetes mellitus aged 59.5 on average. The patients never received insulin nor had an autoantibody to GAD65 prior to insulin therapy.

GAD65 antibody is a pancreatic islet antibody and an important biomarker of predisposition to type 1 diabetes. The study results indicated that these patients were not normally prone to developing type 1 diabetes mellitus.

The study found that after insulin treatment, glucose control got worse and worse quickly without any known reason or cause while c-peptide levels dropped quickly to the level indicating insulin deficiency.

Type 2 diabetes mellitus patients can produce insulin, but the amount of insulin is often not sufficient for it to function normally (insulin insensitivity). Because of this, exogenous insulin is often used to increase the insulin level to help lower blood sugar.

In the study, researchers noticed that insulin-induced type 1 diabetes mellitus developed on average after 7.7 months of insulin administration.

All patients with insulin induced type 1 diabetes mellitus had type 1 diabetes mellitus high risk HLA class II (IDDM1)and the insulin gene VNTR genotype(IDDM 2).

The study concluded "The findings suggest that insulin administration may have triggered TIDM (type 1 diabetes mellitus) in patients with T2DM (type 2 diabetes mellitus)."

The study suggests that IDDM1 and IDDM 2 as well as autoreactive T cells, (the latter was found in some cases) may increase the risk of the development of type 1 diabetes mellitus.

The study also suggests that patients who had their blood sugar control deteriorating acutely after a few months of insulin administration may have developed type 1 diabetes mellitus.

Type 1 diabetes mellitus is harder to treat than type 2 diabetes mellitus. Type 2 diabetes mellitus is very easy to prevent, studies suggest. One Indian study suggest that taking curcumin as a dietary supplement in a dose of six grams per day can effectively prevent prediabetes from progressing into full-blown type 2 diabetes mellitus.

Nishida W, Nagata M, Imagawa A, Hanafusa T, Ohashi J, Takahashi K, Suehiro T, Yamada Y, Chujo D, Kawasaki E, Kawamura R, Onuma H, Osawa H, Makino H. Insulin administration may trigger type 1 diabetes in Japanese type 2 diabetes patients with type 1 diabetes high-risk HLA class II and the insulin gene VNTR genotype. J Clin Endocrinol Metab. 2014 Jun 27:jc20141759\.