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# Probiotic helps prevent breast cancer
- URL: https://www.foodconsumer.org/probiotic_helps_prevent_breast_cancer_0911140505/
- Published: 2014-09-11T18:04:00.000Z
- Updated: 2026-09-22T15:51:33.000Z
- Description: In rats exposed to the carcinogen DMBA, the probiotic Lactobacillus plantarum LS/07, with or without inulin, significantly suppressed tumor frequency, raised CD4+ T cells in tumor tissue and lowered serum TNF-alpha. The authors credit immunomodulatory mechanisms for the effect.
- Author: Food Consumer
- Tags: Biotics, Nutrition, #vivvo-import

Thursday Sep 11, 2014 (foodconsumer.org) -- Breast cancer, a disease that claims more than 37,000 American women each year, in many cases are preventable. Monika Kassayova at P.J. Šafárik University, Košice, Slovak Republic and colleagues published a study suggesting that probiotics when used for a long term can be protective against the development of breast cancer.

The study found supplementation with a new probiotic bacterial strain, Lactobacillus plantarum LS/07 (PRO) along with or without prebiotic oligofructose-enriched inulin prevented breast cancer in rats who were exposed to a carcinogen called 7,12-dimethylbenz\[a\]anthracene (DMBA).

The probiotic was used in a dose of 8.4x10(8) cfu per day in rats and the insulin in a dose of 20 grams per kg. The supplementation started two weeks prior to the exposure to the cancer causing agent and lasted until the end of the 16-week intervention.

 The study showed that administration of the probiotic, the prebiotic and the combination of the two significantly suppressed the tumor frequency, increased Cd4(+) T-cells in tumor tissue and lowered serum tumor necrosis factor-α.

In rats treated with the probiotic and the probiotic-prebiotic combo, Cd8(+) T-cells decreased in blood and increased in tumor tissue.

The study concluded "Long-term administration of Lactobacillus plantarum LS/07 with and without inulin is effective against breast cancer, at least partially, through immunomodulatory mechanisms." (David Liu, PHD)

Kassayová M, Bobrov N, Strojný L, Kisková T, Mikeš J, Deme?ková V, Orendáš P, Bojková B4, Pé? M, Kubatka P, Bomba A. Preventive Effects of Probiotic Bacteria Lactobacillus plantarum and Dietary Fiber in Chemically-induced Mammary Carcinogenesis. Anticancer Res. 2014 Sep;34(9):4969-75.