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# Study examines probiotic use in preventing gastrointestinal disorders in infants (PR)
- URL: https://www.foodconsumer.org/probiotics_gastrointestinal_disorders_0201140847/
- Published: 2014-02-01T09:46:00.000Z
- Updated: 2026-09-22T15:55:41.000Z
- Description: Flavia Indrio of Aldo Moro University and colleagues randomized 554 Italian newborns to Lactobacillus reuteri DSM 17938 or placebo for 90 days. At three months the probiotic group averaged 38 minutes of crying a day against 71, fewer regurgitations, and about $119 lower costs per patient.
- Author: Food Consumer
- Tags: Other Diseases, Avoiding Illness, #vivvo-import

Contact: Flavia Indrio  
[f.indrio@neonatologia.uniba.it](mailto:f.indrio@neonatologia.uniba.it)  
[The JAMA Network Journals](http://www.jamamedia.org/?ref=foodconsumer.org)   

# Study examines probiotic use in preventing gastrointestinal disorders in infants

Giving an infant a probiotic during the first three months of life appears to reduce the onset of gastrointestinal disorders and result in lower associated costs, according to a study by Flavia Indrio, M.D., of the Aldo Moro University of Bari, Italy, and colleagues.

Infant colic, acid reflux and constipation are the most common gastrointestinal disorders that lead to a pediatrician referral during the first six months of life. They are often responsible for hospitalization, feeding changes, use of drugs, parental anxiety and loss of parental working days, according to the study background.

Researchers randomized 554 newborns in nine pediatric units in Italy to the probiotic Lactobacillus reuteri DSM 17938 (L reuteri DSM 17938) or placebo for 90 days, and asked parents to record in diary entries the number of vomiting episodes and evacuations (emptying of the bowels), the duration of inconsolable crying and the number of pediatrician visits. Change in daily crying time, vomiting, constipation and the cost benefits of probiotic supplement use was measured during the three month period.

At three months of age, the average duration of crying time (38 vs. 71 minutes), regurgitations (2.9 vs. 4.6) and evacuations per day (4.2 vs. 3.6) differed in the probiotic and placebo groups, respectively. Probiotic use also was associated with a nearly $119 average savings per patient in each family.

"Driving a change of colonization during the first weeks of life through giving lactobacilli may promote an improvement in intestinal permeability; visceral sensitivity and mast cell density and probiotic administration may represent a new strategy for preventing these conditions, at least in predisposed children," the authors conclude.

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(JAMA Pediatr. Published online January 13, 2014\. doi:10.1001/jamapediatrics.2013.4367\. Available pre-embargo to the media at[http://media.jamanetwork.com](http://media.jamanetwork.com/?ref=foodconsumer.org).)

Editor's Note: This study was supported by BioGaia AB in Sweden. Please see article for additional information, including other authors, author contributions and affiliations, etc.