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# Red wine polyphenol supplements may help Alzheimer's disease
- URL: https://www.foodconsumer.org/red-wine-polyphenol-supplements-may-help-alzheimer-s-disease/
- Published: 2013-08-19T19:30:00.000Z
- Updated: 2026-09-22T16:15:44.000Z
- Description: In mouse brain cell cultures, the red wine polyphenol metabolite quercetin-3-O-glucuronide significantly cut production of beta-amyloid peptides and interfered with the protein interactions that build neurotoxic amyloid oligomers, a laboratory study in the FASEB Journal found.
- Author: Food Consumer
- Tags: Nutrition, #vivvo-import

Monday Aug 19, 2013 (foodconsumer.org) -- Supplementation of a metabolite of red wine polyphenols may help prevent Alzheimer's disease or help patients with the disease, a new study suggests.

The laboratory study found a polyphenol metabolite quercetin-3-O-glucuronide significantly reduced the generation of β-amyloid (Aβ) peptides in in vitro brain cell cultures from mice with a disease similar to Alzheimer's disease.

Previous research has suggested that moderate intake of polyphenols found in red wines may lower the risk for developing dementia, particularly Alzheimer's disease.

Quercetin-3-O-glucuronide is also found capable of interfering with the protein-protein interaction of Aβ1–40 and Aβ1–42 which is necessary for the formation of neurotoxic oligomeric Aβ species.

Giulio Maria Pasinetti from Department of Neurology, Mt. Sinai School of Medicine in New York, NY, USA and colleagues conducted the study and published it in the FASEB Journal.

The researchers concluded "Brain-targeted quercetin-3-O-glucuronide may simultaneously modulate multiple independent AD disease-modifying mechanisms and, as such, may contribute to the benefits of dietary supplementation with red wines as an effective intervention for AD (Alzheimer's disease)." (Reporting by David Liu).