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# Thiazide-type diuretics less likely to cause cardiovascular outcomes in diabetes patients
- URL: https://www.foodconsumer.org/thiazide-type_diuretics_diabetes_0912121129/
- Published: 2012-09-13T00:27:00.000Z
- Updated: 2026-09-22T16:15:23.000Z
- Description: Among 22,418 ALLHAT participants, people who developed diabetes while taking the diuretic chlorthalidone had lower, non-significant risks of cardiovascular, all-cause and non-cardiovascular death than those who developed diabetes on amlodipine or lisinopril.
- Author: Food Consumer
- Tags: Drug, Health News, #vivvo-import

By David Liu, PHD

Wednesday Sept 12, 2012 ([foodconsumer.org](http://www.foodconsumer.org/)) -- Antihypertensive medications thiazide type diuretics have been associated with an increased risk of diabetes, compared with other antihypertensive medications. But a new study suggests that using other antihypertensive medications can lead to more adverse cardiovascular disease consequences than thiazine-type diuretics.

In this study published in Circulation: cardiovascular Quality and Outcomes, Sara L. Pressel, MS, of The University of Texas School of Public Health in Houston, Texas and colleagues compared the long term cardiovascular disease consequences of diuretic-related diabetes with that of incident diabetes related to use of calcium channel blocker and angiotensin-converting enzyme inhibitors.

The study involved 22 418 participants from Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial or simply the ALLHAT with diabetes at baseline, incident diabetes (7.5% with chlorthalidone, 5.6% with amlodipine, and 4.3% with lisinopril), or no diabetes at two years of in-trial follow-up. All participants were followed for a mean total of 2.9 years for the trial and 4 additional years after the trial.

The primary outcome was cardiovascular disease mortality or death from coronary heart disease, stroke, heart failure, or other cardiovascular disease. Other outcomes included all-cause mortality, non-cardiovascular disease mortality, and coronary heart disease (nonfatal myocardial infarction or fatal coronary heart disease). 

Participants on chlorthalidone, a thiazide type diuretic, with incident diabetes, compared with those without diabetes, had lower, nonsignificant risk for cardiovascular disease mortality, all-cause mortality, and non-cardiovascular disease mortality, all less than 5%, than participants on amlodipine or lisinopril with incident diabetes, who were 22 to 53 percent more likely to have more severe cardiovascular disease outcomes.

Participants with incident diabetes were found at 46 percent increased coronary heart disease, compared with those with no diabetes, but those on chlorthalidone were 18 percent less likely to have cardiovascular disease outcomes, compared with those on lisinopril.

The researchers concluded "thiazide-related incident diabetes has less adverse long-term CVD (cardiovascular disease) impact than incident diabetes that develops while on other antihypertensive medications."

Thiazide-type diuretics are antihypertensive medications which increase the volume of water that you pass out from your kidneys. These drugs include bendroflumethiazide, chlortalidone, cyclopenthiazide, indapamide, metolazone, and xipamide.

High blood pressure or hypertension is a medical condition that is relatively easy to control. Some alternative remedies may be used to lower high blood pressure.