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# This sugar boosts risk of hypertension and a myriad of other conditions
- URL: https://www.foodconsumer.org/this_sugar_boosts_risk_of_hypertension_0807110426/
- Published: 2011-08-07T17:24:00.000Z
- Updated: 2026-09-22T15:57:15.000Z
- Description: A Current Hypertension Reports review argues fructose can raise blood pressure through several mechanisms, including uric acid produced by its metabolism, and that the risk climbs alongside a high-salt diet because fructose promotes salt and water reabsorption.
- Author: Food Consumer
- Tags: Heart & Blood, Avoiding Illness, Hypertension, Fructose, #vivvo-import

By David Liu, Ph.D.

Sunday Aug 07, 2011 (foodconsumer.org) -- A report in the Feb 2011 issue of Current Hypertension Reports says fructose can boost the risk of hypertension, which is further associated with heart disease.

The risk can be particularly high when fructose, a sugar in high fructose corn syrup, is used along with a high salt diet because fructose promotes re-adsorption of salt and water in the small intestine and kidney, according to authors M. Madero and colleagues of INC Ignacio Chávez in Mexico City, Mexico.

Madero et al say fructose exerts an effect through multiple mechanisms and one major effect of this sugar on major organs like the kidney, endothelium and heart comes from byproducts of its metabolism including uric acid.

One particular organ that is sensitive to the effect of fructose is the kidney because high loads of this sugar can reach the kidney tissue.

The authors say epidemiological studies have already associated with fructose consumption of high risk of hypertension.

It is not new that fructose is linked with risk of hypertension, obesity and metabolic syndrome, diabetes, kidney disease and cardiovascular disease. 

R.J. Johnson of University of Florida reported evidence in the Oct 2007 issue of the American Journal of Clinical Nutrition to suggest that fructose plays a unique role in cardiorenal disease and uric acid as a metabolite byproduct of fructose may explain why fructose has an effect on the disease.

Johnson et al suggests that high intake of fructose in African Americans explain why they are at higher risk of developing cardiorenal disease.