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# Vitamin D supplements help vitamin D deficient type 2 diabetes mellitus patients
- URL: https://www.foodconsumer.org/vitamin_d_supplement_type_2_diabetes_0117150522/
- Published: 2015-01-17T18:22:00.000Z
- Updated: 2026-09-22T16:01:55.000Z
- Description: In a double-blind trial of 81 type 2 diabetes patients with vitamin D of 10-30 ng/mL, 50,000 IU weekly for eight weeks normalized vitamin D and lowered fasting glucose, insulin and HOMA-IR but left adiponectin unchanged. The authors say eight weeks may have been too short.
- Author: Food Consumer
- Tags: Vitamins, Nutrition, #vivvo-import

Saturday Jan 17, 2015 (foodconsumer.org) -- A study in the Sep. 2014 issue of Iranian Red Crescent Medical Journal suggests that supplementation with 50000 IU per week for 8 weeks help type 2 diabetes mellitus with insufficient or deficient vitamin D to lower the levels of fasting serum glucose, insulin, and HOMA-IR.

Early studies have associated serum 25-hydroxyvitamin D and adiponectin inversely with type 2 diabetes and insulin resistance. Diabetes mellitus patients are often vitamin D deficient. The current study was intended to examine the effect of therapeutic dose of vitamin D on adiponectin and insulin resistance in vitamin D insufficient or deficient type 2 diabetes mellitus patients.

In the double-blind, randomized, clinical trial, 81 type 2 diabetic patients with vitamin D levels of 10-30 ng/mL received 50000 IU vitamin D or placebo once a week for 8 weeks. All relevant parameters were measured at baseline and the end of the trial.

Supplementation with vitamin D significantly increased serum 25-hydroxyvitamin D to a normal level and decreased the levels of fasting serum glucose, insulin and HOMA-IR while controls did not experience the same reductions in these parameters.

However, vitamin D supplementation did not change serum adiponectin levels which are directly related to insulin sensitivity.

The researchers concluded "Therapeutic dose of vitamin D can improve vitamin D status and glycemic indicators. But it seems that an 8-week intervention period was not sufficient to reveal the possible effects of vitamin D on serum adiponectin levels." (David Liu, PH.D.)

*Baziar N, Jafarian K, Shadman Z, Qorbani M, Khoshniat Nikoo M, Abd Mishani M. Effect of therapeutic dose of vitamin d on serum adiponectin and glycemia in vitamin d-insufficient or deficient type 2 diabetic patients. Iranian Red Crescent Medical Journal. 2014 Sep 5;16(9):e21458.*