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# Vitamin E prevents stroke-induced injury
- URL: https://www.foodconsumer.org/vitamin_e_prevents_stroke-induced_injury_0706110943/
- Published: 2011-07-07T10:41:00.000Z
- Updated: 2026-09-22T15:44:00.000Z
- Description: Ohio State researchers report that alpha-tocotrienol, a form of vitamin E, clears oxidized glutathione that would otherwise kill neurons, and that oral supplementation helped prevent strokes and stroke-induced injury in rodents by raising MRP1 expression.
- Author: Food Consumer
- Tags: Vitamins, Nutrition, Vitamin E, Stroke, Tocotrienol, #vivvo-import

By David Liu, Ph.D. and editing by Aimee Keenan-Greene

Thursday July 07, 2011 (foodconsumer.org) -- A new study has found maintaining high levels of certain types of vitamin E may help prevent strokes or mitigate the damage induced by a stroke.

[Alpha-tocotrienol](https://www.foodconsumer.org/tocotrienol%5F0706111003/) (TCT), one of the vitamin E tested in the study, helped clear the oxidized glutathimone or glutathimione disulfie (GSSG).

Glutathione is a reducing compound in the liver that helps detoxify many toxic chemicals. This compound can be oxidized under stress, a condition in which a stroke may occur. 

Dr. Han-A Park and colleagues of Ohio State University found build-up of the GSSG, or oxidized glutathione, kills neurons. The use of alpha-tocotrienol can help reduce the levels of this compound preventing cells from being killed when a stroke strikes.

The study was published online June 30, 2011 in the journal Stroke.

During in vivo testing, oral supplementation of alpha-tocotrienol was found to help prevent strokes and stroke induced injury in rodents.

Dr. Park, who conducted the research on how alpha-tocotrienol reduces the risk of stroke for his doctoral degree, also found that multi-drug resistance-associated protein 1 (MRP1) participates in the glutathione-involved detoxification process.

When alpha-tocotrienol was supplemented, MRP1 expression was increased. And the researchers also found that oral alpha-TCT was able to regulate the production of of microRNA (miR)-199a-5p in brain tissue post stroke. And MRP1 is believed to be a target of microRNA (miR)-199a-5p.

Dr. Park and colleagues say alpha-tocotrienol is the most potent form of vitamin E that protect neurons from being injuried by an event like stroke.

The age-adjusted stroke death rate for U.S. residents ages 35 and older was 121/100,000 during 1991-1998, according to the U.S. Centers for Disease Control and Prevention.

The study sheds light on the importance of both vitamin E and glutathione. Food Consumers should consider having sufficient vitamin E and glutathione in their diet or supplements.

Reference:

Title: Natural Vitamin E α-Tocotrienol Protects Against Ischemic Stroke by Induction of Multidrug Resistance-Associated Protein 1

Authors: Han-A Park, PhD; Natalia Kubicki, BS; Surya Gnyawali, PhD; Yuk Cheung Chan, PhD; Sashwati Roy, PhD; Savita Khanna, PhD; Chandan K. Sen, PhD 

Affiliation: From the Department of Surgery, Davis Heart and Lung Research Institute, Ohio State University Medical Center, Columbus, Ohio 43210.

Publication: Published online June 30, 2011 in Stroke

photo credit: wikipedia