Are CoQ10 supplements recommended for cancer patients?

A: Coenzyme Q10 (CoQ10, also known as ubiquinone) is a naturally occurring antioxidant supplied mainly by production within our bodies, but also found in trace amounts in meat, poultry, fish, and some oils and nuts. Supplements are often promoted as a way to prevent heart disease and cancer, but research-established benefits are not nearly as clear as some claims suggest. Certain highly effective chemotherapy medications face limited use because of heart-damaging effects. Some researchers suggest that CoQ10 supplements could help prevent this damage and allow more effective treatment doses, but studies show inconsistent results. Other studies, which used the supplements along with tamoxifen in breast cancer treatment, demonstrated increased signs of DNA repair enzymes and decreased signs of cancer cells spreading throughout the body. However, larger clinical trials to test these possibilities are needed; some animal research suggests boosting CoQ10 antioxidant levels could work against chemotherapy and radiation therapy. CoQ10 could also work against blood thinner medications like warfarin. On the other hand, statin medications that lower blood cholesterol may decrease body production of CoQ10, so doctors may advise supplements for some people. Bottom line: We need more research, and anyone considering CoQ10 supplements should discuss benefits and risks carefully with their doctor.

By Karen Collins, MS, RD, CDN
American Institute for Cancer Research