Dietary supplements and Alzheimer’s disease

A roundup of research citations on Alzheimer's disease: high serum homocysteine, head trauma, alcohol and tobacco appear on the risk side, while vitamin E and C, B vitamins, resveratrol, omega-3 fats and melatonin may help prevent or ease symptoms, though the studies disagree.

By Food Consumer · 2 min read

Some interesting research reports are cited below. It seems that high serum homocysteine, head trauma and alcohol and tobacco are linked to high risk of Alzheimer’s disease while dietary supplements antioxidants such as vitamin E and C, resveratrol, B vitamins and omega 3 fatty acids such as DHA found in oily fish and melatonin may help prevent or relieve symptoms of Alzheimer’s disease although not all studies are consistent. Specifically, carnitine, choline, curcumin, folic acid, fruits and vegetables, thiamin, vitamin B6, vitamin B12 and vitamin E among others may help prevent Alzheimer's disease, according to Linus Pauling Institute. Also anything such as high iron in meat that promotes oxidation or increases oxidative stress can increase the risk of Alzheimer's disease.

Plasma homocysteine as a risk factor for dementia andAlzheimer's disease

S Seshadri, A Beiser, J Selhub… - … England Journal of …, 2002 - Mass Medical Soc

Early vitamin E supplementation in young but not aged mice reduces Aβ levels and amyloid deposition in a transgenic model of Alzheimer's disease

S Sung, Y Yao, K Uryu, H Yang, VMY LEE… - The FASEB Journal, 2004 - FASEB

Head trauma as a risk factor for Alzheimer's disease: a collaborative re-analysis of case-control studies

JA Mortimer, CM Van Duijn, V Chandra… - International journal of …, 1991 - IEA

Vitamin E and vitamin C supplement use and risk of incident Alzheimer disease

MC Morris, LA Beckett, PA Scherr… - Alzheimer Disease & …, 1998 - journals.lww.com

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

SS Karuppagounder, JT Pinto, H Xu, HL Chen… - Neurochemistry …, 2009 - Elsevier

Dietary factors and Alzheimer's disease

JA Luchsinger, R Mayeux - The Lancet Neurology, 2004 - Elsevier