13^th Report on Carcinogens

U.S. Department of Health and Human Services Secretary Sylvia M. Burwell released the 13^th Report on Carcinogens on October 2, 2014. The Report on Carcinogens (RoC) is a congressionally mandated, science-based, public health document that the National Toxicology Program prepared for the HHS Secretary.

The report identifies agents, substances, mixtures, and exposure circumstances that are known or reasonably anticipated to cause cancer in humans.

This cumulative report includes 243 listings since 1980 and replaces previous editions.

Visit the RoC website: http://ntp.niehs.nih.gov/go/roc13.

Table of Contents

• Introduction(150 KB)
• Review Process(310 KB)
• Substances Listed (320 KB)
• Substance Profiles
• Supplemental Materials and Appendices

Substance Profiles

• A
• Acetaldehyde(148 KB)
• 2-Acetylaminofluorene(92 KB)
• Acrylamide(129 KB)
• Acrylonitrile(115 KB)
• Adriamycin(87 KB)
• Aflatoxins(113 KB)
• Alcoholic Beverage Consumption(79 KB)
• 2-Aminoanthraquinone(77 KB)
• o-Aminoazotoluene(79 KB)
• 4-Aminobiphenyl(101 KB)
• 1-Amino-2,4-dibromoanthraquinone(85 KB)
• 1-Amino-2-methylanthraquinone(76 KB)
• Amitrole(96 KB)
• o-Anisidine and Its Hydrochloride(97 KB)
• Aristolochic Acids(177 KB)
• Arsenic and Inorganic Arsenic Compounds(122 KB)
• Asbestos(116 KB)
• Azacitidine(96 KB)
• Azathioprine(108 KB)
• B
• Basic Red 9 Monohydrochloride(82 KB)
• Benzene(115 KB)
• Benzidine and Dyes Metabolized to Benzidine(145 KB)
  • Benzidine
  • Dyes Metabolized to Benzidine (Benzidine Dye Class)
• Benzotrichloride(94 KB)
• Beryllium and Beryllium Compounds(115 KB)
• 2,2-Bis(bromomethyl)-1,3-propanediol (Technical Grade)(81 KB)
• Bis(chloromethyl) Ether and Technical-Grade Chloromethyl Methyl Ether(91 KB)
• Bromodichloromethane(100 KB)
• 1-Bromopropane (165 KB)
• 1,3-Butadiene(132 KB)
• 1,4-Butanediol Dimethanesulfonate(74 KB)
• Butylated Hydroxyanisole(94 KB)
• C
• Cadmium and Cadmium Compounds(130 KB)
• Captafol(130 KB)
• Carbon Tetrachloride(117 KB)
• Ceramic Fibers (Respirable Size)(85 KB)
• Chlorambucil(84 KB)
• Chloramphenicol(107 KB)
• Chlorendic Acid(86 KB)
• Chlorinated Paraffins (C12, 60% Chlorine)(95 KB)
• Chloroform(128 KB)
• 3-Chloro-2-methylpropene(88 KB)
• 4-Chloro-o-phenylenediamine(77 KB)
• Chloroprene(109 KB)
• p-Chloro-o-toluidine and Its Hydrochloride(114 KB)
• Chromium Hexavalent Compounds(150 KB)
• Cisplatin(95 KB)
• Coal Tars and Coal-Tar Pitches(95 KB)
• Cobalt Sulfate (101 KB)
• Cobalt-Tungsten Carbide: Powders and Hard Metals (205 KB)
• Coke-Oven Emissions(81 KB)
• p-Cresidine(86 KB)
• Cumene (146 KB)
• Cupferron(76 KB)
• Cyclophosphamide(92 KB)
• Cyclosporin A(121 KB)
• D
• Dacarbazine(85 KB)
• Danthron(87 KB)
• 2,4-Diaminoanisole Sulfate(84 KB)
• 2,4-Diaminotoluene(97 KB)
• Diazoaminobenzene(89 KB)
• 1,2-Dibromo-3-chloropropane(96 KB)
• 1,2-Dibromoethane(124 KB)
• 2,3-Dibromo-1-propanol(79 KB)
• 1,4-Dichlorobenzene(112 KB)
• 3,3'-Dichlorobenzidine and Its Dihydrochloride(112 KB)
• Dichlorodiphenyltrichloroethane(115 KB)
• 1,2-Dichloroethane(124 KB)
• Dichloromethane(111 KB)
• 1,3-Dichloropropene (Technical Grade)(124 KB)
• Diepoxybutane(83 KB)
• Diesel Exhaust Particulates(125 KB)
• Di(2-ethylhexyl) Phthalate(128 KB)
• Diethylstilbestrol(110 KB)
• Diethyl Sulfate(90 KB)
• Diglycidyl Resorcinol Ether(79 KB)
• 3,3'-Dimethoxybenzidine and Dyes Metabolized to 3,3'-Dimethoxybenzidine(146 KB)
  • 3,3'-Dimethoxybenzidine
  • Dyes Metabolized to 3,3'-Dimethoxybenzidine (3,3'-Dimethoxybenzidine Dye Class)
• 4-Dimethylaminoazobenzene(92 KB)
• 3,3'-Dimethylbenzidine and Dyes Metabolized to 3,3'-Dimethylbenzidine(137 KB)
  • 3,3'-Dimethylbenzidine
  • Dyes Metabolized to 3,3'-Dimethylbenzidine (3,3'-Dimethylbenzidine Dye Class)
• Dimethylcarbamoyl Chloride(80 KB)
• 1,1-Dimethylhydrazine(95 KB)
• Dimethyl Sulfate(90 KB)
• Dimethylvinyl Chloride(77 KB)
• 1,4-Dioxane(127 KB)
• Disperse Blue(89 KB)
• E
• Epichlorohydrin(127 KB)
• Erionite(75 KB)
• Estrogens, Steroidal(136 KB)
• Ethylene Oxide(137 KB)
• Ethylene Thiourea(117 KB)
• Ethyl Methanesulfonate(79 KB)
• F
• Formaldehyde(372 KB)
• Furan(117 KB)
• G
• Certain Glass Wool Fibers (Inhalable)(261 KB)
• Glycidol(87 KB)
• H
• Hepatitis B Virus(94 KB)
• Hepatitis C Virus(102 KB)
• Heterocyclic Amines (Selected)(175 KB)
  • 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline
  • 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline
  • 2-Amino-3-methylimidazo[4,5-f]quinoline
  • 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
• Hexachlorobenzene(122 KB)
• Hexachloroethane(114 KB)
• Hexamethylphosphoramide(90 KB)
• Human Papillomaviruses: Some Genital-Mucosal Types(109 KB)
• Hydrazine and Hydrazine Sulfate(126 KB)
• Hydrazobenzene(93 KB)
• I
• Ionizing Radiation(283 KB)
  • X-Radiation and Gamma Radiation
  • Neutrons
  • Radon
  • Thorium Dioxide
• Iron Dextran Complex(73 KB)
• Isoprene(138 KB)
• J
• None
• K
• Kepone(91 KB)
• L
• Lead and Lead Compounds(166 KB)
• Lindane, Hexachlorocyclohexane (Technical Grade), and Other Hexachlorocyclohexane Isomers(121 KB)
• M
• Melphalan(83 KB)
• Methoxsalen with Ultraviolet A Therapy(94 KB)
• 2-Methylaziridine(92 KB)
• 4,4'-Methylenebis(2-chloroaniline)(109 KB)
• 4,4'-Methylenebis(N,N-dimethyl)benzenamine(90 KB)
• 4,4'-Methylenedianiline and Its Dihydrochloride(106 KB)
• Methyleugenol(100 KB)
• Methyl Methanesulfonate(76 KB)
• Metronidazole(91 KB)
• Michlers Ketone(116 KB)
• Mineral Oils: Untreated and Mildly Treated(83 KB)
• Mirex(105 KB)
• Mustard Gas(83 KB)
• N
• Naphthalene(111 KB)
• 2-Naphthylamine(91 KB)
• Nickel Compounds and Metallic Nickel(150 KB)
  • Nickel Compounds
  • Metallic Nickel
• Nitrilotriacetic Acid(93 KB)
• o-Nitroanisole(90 KB)
• Nitroarenes (Selected)(227 KB)
  • 1,6-Dinitropyrene
  • 1,8-Dinitropyrene
  • 6-Nitrochrysene
  • 1-Nitropyrene
  • 4-Nitropyrene
• Nitrobenzene(99 KB)
• Nitrofen(87 KB)
• Nitrogen Mustard Hydrochloride(92 KB)
• Nitromethane(100 KB)
• 2-Nitropropane(97 KB)
• N-Nitrosamines: 15 Listings(940 KB)
  • N-Methyl-N'-Nitro-N-Nitrosoguanidine
  • N-Nitrosodi-n-butylamine
  • N-Nitrosodiethanolamine
  • N-Nitrosodiethylamine
  • N-Nitrosodimethylamine
  • N-Nitrosodi-n-propylamine
  • N-Nitroso-N-ethylurea
  • 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
  • N-Nitroso-N-methylurea
  • N-Nitrosomethylvinylamine
  • N-Nitrosomorpholine
  • N-Nitrosonornicotine
  • N-Nitrosopiperidine
  • N-Nitrosopyrrolidine
  • N-Nitrososarcosine
• Nitrosourea Chemotherapeutic Agents(233 KB)
  • Bis(chloroethyl) Nitrosourea
  • 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
  • 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
  • Chlorozotocin
  • Streptozotocin
• o-Nitrotoluene(138 KB)
• Norethisterone(86 KB)
• O
• Ochratoxin A(114 KB)
• 4,4'-Oxydianiline(90 KB)
• Oxymetholone(135 KB)
• P
• Pentachlorophenol and By-products of Its Synthesis (229 KB)
• Phenacetin and Analgesic Mixtures Containing Phenacetin(89 KB)
  • Phenacetin
  • Analgesic Mixtures Containing Phenacetin
• Phenazopyridine Hydrochloride(81 KB)
• Phenolphthalein(111 KB)
• Phenoxybenzamine Hydrochloride(79 KB)
• Phenytoin and Phenytoin Sodium(103 KB)
• Polybrominated Biphenyls(102 KB)
• Polychlorinated Biphenyls(154 KB)
• Polycyclic Aromatic Hydrocarbons: 15 Listings(329 KB)
  • Benz[a]anthracene
  • Benzo[b]fluoranthene
  • Benzo[j]fluoranthene
  • Benzo[k]fluoranthene
  • Benzo[a]pyrene
  • Dibenz[a,h]acridine
  • Dibenz[a,j]acridine
  • Dibenz[a,h]anthracene
  • 7H-Dibenzo[c,g]carbazole
  • Dibenzo[a,e]pyrene
  • Dibenzo[a,h]pyrene
  • Dibenzo[a,i]pyrene
  • Dibenzo[a,l]pyrene
  • Indeno[1,2,3-cd]pyrene
  • 5-Methylchrysene
• Procarbazine and Its Hydrochloride(93 KB)
• Progesterone(100 KB)
• 1,3-Propane Sultone(88 KB)
• β-Propiolactone(96 KB)
• Propylene Oxide(103 KB)
• Propylthiouracil(87 KB)
• Q
• None
• R
• Reserpine(98 KB)
• Riddelliine(123 KB)
• S
• Safrole(93 KB)
• Selenium Sulfide(90 KB)
• Silica, Crystalline (Respirable Size)(93 KB)
• Soots(69 KB)
• Strong Inorganic Acid Mists Containing Sulfuric Acid(117 KB)
• Styrene(291 KB)
• Styrene-7,8-oxide(103 KB)
• Sulfallate(78 KB)
• T
• Tamoxifen(114 KB)
• 2,3,7,8-Tetrachlorodibenzo-p-dioxin(118 KB)
• Tetrachloroethylene(112 KB)
• Tetrafluoroethylene(97 KB)
• Tetranitromethane(87 KB)
• Thioacetamide(84 KB)
• 4,4'-Thiodianiline(92 KB)
• Thiotepa(87 KB)
• Thiourea(86 KB)
• Tobacco-Related Exposures(173 KB)
  • Tobacco Smoking
  • Environmental Tobacco Smoke
  • Smokeless Tobacco
• Toluene Diisocyanates(126 KB)
• o?Toluidine (171 KB)
• Toxaphene(118 KB)
• Trichloroethylene(141 KB)
• 2,4,6-Trichlorophenol(103 KB)
• 1,2,3-Trichloropropane(109 KB)
• Tris(2,3-dibromopropyl) Phosphate(94 KB)
• U
• Ultraviolet Radiation Related Exposures(150 KB)
  • Solar Radiation
  • Exposure to Sunlamps or Sunbeds
  • Broad-Spectrum UVR
  • UVA
  • UVB
  • UVC
• Urethane(107 KB)
• V
• 4-Vinyl-1-cyclohexene Diepoxide(88 KB)
• Vinyl Halides (Selected)(200 KB)
  • Vinyl Bromide
  • Vinyl Chloride
  • Vinyl Fluoride
• W
• Wood Dust(95 KB)
• X - Z
• None

Supplemental Materials and Appendices

• Glossary(229 KB)
• Acronyms and Abbreviations(92 KB)
• Units of Measurement(99 KB)
• All Appendices(399 KB)
  • Appendix A: Manufacturing Processes, Occupations, and Exposure Circumstances Classified By IARC As Category 1, Carcinogenic To Humans(83 KB)
  • Appendix B: Substances Delisted from the Report on Carcinogens (150 KB)
  • Appendix C: Substances Reviewed but Not Recommended for Listing in the Report on Carcinogens(81 KB)
  • Appendix D: List of Participants (122 KB)
  • Appendix E: Chemicals Nominated to the NTP for In-Depth Toxicological Evaluation (77 KB)
  • Appendix F: Substance Names and Common Synonyms (178 KB)
  • Appendix G: List of Substances by CAS Number (101 KB)