Thursday Feb 4, 2016 (foodconsumer.org) -- Eating sugar increases risk of breast cancer and its lung metastasis, according to a new report in Cancer Research.The study finds that sucrose or sugar increases risk of breast cancer by increasing the production of 12-lipoxygenase, which catalyzes oxidation of arachidonic acid into 12-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12-HETE), a metabolite found high in breast cancer mass. Specifically, fructose which accounts for 50% of sucrose (the remaining 40% is glucose) was found to be responsible for lung metastasis and 12-HETE production. The study seems to suggest that breast cancer patients should avoid eating sucrose or sugar. (David Liu)Yan Jiang, Yong Pan, Patrea R. Rhea, Lin Tan, Mihai Gagea, Lorenzo Cohen, Susan M. Fischer, and Peiying Yang, A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway, Cancer Res January 1, 2016 76; 24
Cancer Public
Eating sugar increases breast cancer risk
A Cancer Research report finds sucrose raised breast cancer and lung metastasis risk in part by increasing 12-lipoxygenase, which produces 12-HETE, a metabolite found at high levels in breast tumors. Fructose, half of sucrose, accounted for the metastasis and the 12-HETE production.
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