Monday June 17, 2013 (foodconsumer.org) -- A study in Europe PubMed Central suggests that eating meat and dairy products may worsen the outcome of prostate cancer, compared with eating plant-based foods.

The study led by E. L. Richman and colleagues revealed that eating carbohydrates and animal fat after diagnosis of prostate cancer may increase the risk of dying from all causes.  Because animal fat is often present in meat and dairy products, and the association means that eating meat and dairy products may be bad for prostate cancer patients.

In the U.S., nearly 2.5 million men now live with prostate cancer, the authors of the study report say.  Few studies were intended to understand the association between posdiagnostic diet and prostate cancer progression and overall mortality.  The current study was meant to examine the association between postdiagnostic fat intake and risk for lethal prostate cancer and all-cause mortality. 

A total of 4577 men with nonmetastatic prostate cancer were enrolled in the Health Professionals Follow-up Study (1986-2010).   Researchers surveyed participants for their postdiagnostic intake of different types of fat including saturated, monounsaturated, polyunsaturated, trans, animal, and vegetable fat and disease conditions and outcomes.   During the 8.4 year follow-up, 315 events of lethal prostate cancer and 1064 deaths were recorded.

The researchers reported "crude rates per 1000 person-years for lethal prostate cancer were as follows (highest vs lowest quintile of fat intake): 7.6 vs 7.3 for saturated, 6.4 vs 7.2 for monounsaturated, 5.8 vs 8.2 for polyunsaturated, 8.7 vs 6.1 for trans, 8.3 vs 5.7 for animal, and 4.7 vs 8.7 for vegetable fat."  The findings mean that eating saturated fat, trans fat, particularly animal fat is bad for the prognosis of prostate cancer while eating monounsaturated fat and polyunsaturated fat and vegetable fat is good for the outcome of prostate cancer.

Similarly, the type of fat can also influence the risk of death from all causes.  The researchers reported "For all-cause mortality, the rates were 28.4 vs 21.4 for saturated, 20.0 vs 23.7 for monounsaturated, 17.1 vs 29.4 for polyunsaturated, 32.4 vs 17.1 for trans, 32.0 vs 17.2 for animal, and 15.4 vs 32.7 for vegetable fat."  The associations were similar to those for lethal prostate cancer rates.

Exactly, the researchers also found replacing 10% of energy intake from carbohydrate with vegetable fat was associated with a 29% reduced lower risk of lethal prostate cancer and a 26% reduced risk for all-cause mortality. 

"Saturated and trans fats after diagnosis (replacing 5% and 1% of energy from carbohydrate, respectively) were associated with higher all-cause mortality (HR, 1.30 [95% CI, 1.05-1.60; P = .02] and 1.25 [95% CI, 1.05-1.49; P = .01], respectively)," wrote the researchers.

The researchers concluded "Among men with nonmetastatic prostate cancer, replacing carbohydrates and animal fat with vegetable fat may reduce the risk of all-cause mortality."

This is not the first study that finds the association between postdiagnostic animal fat intake and increased risk for lethal prostate cancer and death from all causes. (reporting by Jimmy Downs)

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