An animal study indicates that resveratrol supplements may be used alone or in combination with cisplatin to inhibit the growth of ovarian cancer or prevent the disease.
Previous studies have already suggested that resveratrol supplements suppress the growth of ovarian cancer by inhibiting glucose metabolism and inducing both autophage and apoptosis.
For the current study, mice with implanted ovarian cancer cells were treated with cisplatin followed by either daily resveratrol supplements or placebo.
The study shows that mice treated with both resveratrol and cisplatin had a significantly reduced cancer burden, compared to those controls.
When mice were treated only with resveratrol, the uptake of glucose by tumors was significantly reduced, compared to that of the controls, meaning that resveratrol affects the glucose metabolism in cancer cells.
Among mice treated with cisplatin, resveratrol supplements provide a protective effect to suppress tumor regrowth, compared with mice treated with placebo only. This indicates that resveratrol supplements can help cancer free survival.
Evidence also suggests that resveratrol supplements inhibit glycolysis in ovarian cancer cells, which is highly at baseline, and induces autophage.
The study concludes that "Treatment with resveratrol inhibits glucose uptake and has a significant antineoplastic effect in a preclinical mouse model of ovarian cancer."
And also resveratrol supplements may be used to prolong disease free survival in patients with ovarian cancer because this phytochemical suppresses tumor regrowth after therapy with cisplatin.
Resveratrol is found in red wine and red grapes and many other foods like peanuts, blueberries, cranberries, and cocoa and dark choclate. To have a therapeutical effect, higher doses need to be used. (David Liu)
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