Jay Fournier and colleagues reviewed six trials covering 718 patients and found antidepressant efficacy depended heavily on how severe depression was at the outset, with meaningful benefit concentrated in severe cases and little to show for mild or moderate symptoms.
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Antidepressants raise risk of death and stroke in older women
In the Women's Health Initiative, which followed 160,000 postmenopausal women for up to 15 years, those taking tricyclic or SSRI antidepressants were 45 percent more likely to have a stroke, especially the bleeding kind, and in one analysis 32 percent more likely to die.
Drug
Before You Take That Antidepressant, Visit This Web Site
SSRIstories.com collects 3,500 crime-related news reports involving SSRI antidepressants, sortable by drug, date, location and type of violence, with each story's drug citation pulled out and boldfaced. A 2009 Journal of American Physicians and Surgeons article cited the site.
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