Michele Petruzzelli and colleagues at Spain's CNIO report in Cell Metabolism that cachexia, which they say kills a third of cancer patients, is triggered by the conversion of white fat into brown fat, the same process studied as a way to fight obesity.
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Disease
Disease news, from thyroid problems to autism.
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Disease
Kidney stones linked to cardiovascular disease
Pooling six cohort studies, researchers linked kidney stones to 19% higher coronary heart disease risk and 40% higher stroke risk, with a stronger association in women. The piece notes the link does not show stones cause cardiovascular disease.
Disease
Sexually transmitted diseases may raise prostate cancer risk
A systematic review of 47 studies published between 1971 and 2011 found men who had ever had a sexually transmitted infection faced a 49 percent higher risk of prostate cancer, with gonorrhoea specifically linked to a 20 percent higher risk.
Disease
Melasma: Tips To Make It Less Noticeable
Dermatologist Bethanee Schlosser advises daily broad-spectrum sunscreen of SPF 30 or higher with zinc oxide or titanium dioxide, a wide-brimmed hat, shade and gentle skin care products to make the brown to gray-brown facial patches less noticeable. Sunlight is a common trigger.
Disease
NIH study finds extreme obesity may shorten life expectancy up to 14 years
Pooling data from 20 studies across three countries, NCI researchers reported in PLOS Medicine that adults with class III obesity face higher risks of dying young from cancer, heart disease, stroke, diabetes and kidney and liver disease, and lose years of life expectancy.
Disease
Diabetes mellitus linked to Alzheimer's disease
A Taiwanese study of a million National Health Insurance records found diabetics were 76% more likely to be diagnosed with Alzheimer's over 11 years, 0.48% versus 0.37%. The writer stresses this is an association, not evidence that one disease causes the other.
Disease
Insulin-like growth factor–1 new risk factor for Alzheimer's disease?
A family study comparing offspring of parents with and without Alzheimer's found those with a family history were more likely to carry an APOE allele and to have higher serum IGF-1. The authors conclude higher midlife IGF-1 is associated with later Alzheimer's risk, independent of APOE.
Disease
WSU researchers rule out leading hypothesis for miscarriages, birth defects
WSU researchers counted chromosome crossovers in thousands of eggs and found no difference between those formed early and late in fetal development, contradicting the 46-year-old production-line hypothesis for why older women face more miscarriages.
Disease
Hyperthermia: too hot for your health
The National Institute on Aging warns that older adults and people with chronic conditions face higher risk of heat stroke, heat syncope, heat cramps and heat exhaustion, and advises staying in air conditioning or heading to senior centers, malls, theaters or libraries on hot, humid days.
Disease
Insulin therapy for type 2 diabetes mellitus can cause type 1 diabetes mellitus
A Japanese study of six type 2 diabetes patients, averaging 59.5 years, found glucose control deteriorated and C-peptide dropped to insulin-deficient levels an average 7.7 months after insulin therapy began. All carried high-risk HLA class II and insulin gene VNTR genotypes.
Disease
Inflammatory disorders boost risk of diabetes mellitus, cardiovascular disease
UK primary care data show patients with chronic inflammatory disorders faced 20 percent higher risk of type 2 diabetes and cardiovascular disease overall, rising to 32 percent with systemic autoimmune disorders. Risk tracked with inflammation severity. Published in Circulation.
Disease
Breast Cancer—Men Get It Too
About 2,000 US men are diagnosed with breast cancer each year, 1% of all cases, and fewer than 500 die. FDA oncologist Tatiana Prowell says men have historically been excluded from breast cancer trials, so they are treated much as women are.
Disease
Breast Cancer Treatment (PDQ®)
An NCI patient summary covering how malignant cells form in breast tissue, the lobes and ducts of the breast, the effect of health history and inherited gene mutations on risk, signs such as a lump, the tests used to find and diagnose the disease, and what shapes prognosis and treatment options.
Disease
HPV can also cause breast cancer
In an Iraqi study, mixed HPV genotypes turned up in 46.5% of tissue samples from 129 breast cancer patients, against three of 24 patients with benign tumors and none of 20 healthy women. The authors say the finding supports a possible role for the virus in breast cancer.
Disease
Renal cell carcinoma patients with diabetes mellitus less likely to survive
Among 1,964 surgically treated clear cell renal cell carcinoma patients, those with diabetes were 55% more likely to die of the cancer and 32% more likely to die of any cause after adjustment, a Journal of Urology study reports. Five-year overall survival was worse with diabetes.
Disease
Mental Health Expert Advises Parents How to Talk to Children About Recent School Violence
Mental health expert Dr. Gregory Jantz urges parents to talk with their children about recent school shootings right away, let the child lead the conversation, and pitch it to the child's developmental age, so the trauma does not settle into long-term PTSD.
Disease
National Diabetes Statistics Report, 2014
CDC figures for 2012: 29.1 million Americans, 9.3 percent of the population, have diabetes, including 8.1 million who are undiagnosed. Among adults 20 and older, 12.3 percent have the disease, rising to 25.9 percent of those 65 and older.
Disease
Diabetes Toll Worsens
A CDC report counted 29.1 million Americans with diabetes and 86 million adults with prediabetes in 2012, up from 25.8 million and 79 million in 2010. The agency puts the estimated annual cost at $245 billion.
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