Mercola relays oncology dietitian Sharlene Bidini's critique of a Journal of Infectious Diseases study reporting high HPV vaccine effectiveness: its conclusion rested on 740 girls, only 358 of them sexually active, and just 111 who had received even one dose.
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Drug
Prescription drugs, vaccines and their risks and benefits.
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Drug
New Female Sex Drug May Treat Sexual Side Effects of Antidepressants
Older and newer antidepressants often cause diminished libido and anorgasmia; one study found 96 percent of patients on a particular drug developed anorgasmia. A Dutch company says its unapproved drugs Lybrido and Lybridos, pairing testosterone with sildenafil or buspirone, may help.
Drug
Statins boost breast cancer risk
In a case-control study of women aged 55 to 74, those who had taken statins for 10 years or more were 83 percent more likely to have invasive ductal carcinoma and 97 percent more likely to have invasive lobular carcinoma than women who never used them.
Drug
FDA approves the first non-hormonal treatment for hot flashes associated with menopause
The FDA approved Brisdelle, which contains the SSRI paroxetine mesylate, as the first non-hormonal treatment for moderate to severe hot flashes in menopause. Approval rested on two randomized, placebo-controlled studies in 1,175 postmenopausal women lasting 12 and 24 weeks.
Drug
Breast cancer patients receiving radiation more likely to have heart failure
Among 8,025 women treated with radiation between 1976 and 2007 in SEER registries, about 13% were later diagnosed with heart failure. Black patients had a 40% higher risk than other races after adjusting for age, diabetes, blood pressure, chemotherapy and cardioprotective drugs.
Drug
Hormone replacement therapy increases breast cancer risk, death risk
Over 11 years of follow-up among 41,449 postmenopausal women in the Women's Health Initiative, users of estrogen plus progestin were 55 percent more likely than nonusers to develop breast cancer, 32 percent more likely to die of it and 65 percent more likely to die of any cause.
Drug
FDA Approves Denosumab for Treatment of Giant Cell Turmor of Bone
The FDA approved denosumab (Xgeva) for adults and skeletally mature adolescents whose giant cell tumor of bone cannot be removed or where surgery risks severe harm. Across two open-label trials, 47 of 187 evaluable patients had a partial response, a 25 percent response rate.
Drug
Caffeine-containing medicines increases risk of hemorrhagic stroke
A case-control study in Stroke compared 940 hemorrhagic stroke patients with 1,880 controls and found that using caffeine-containing medicines was associated with 123 percent higher risk. Among people who did not drink coffee daily, the increase was 195 percent.
Drug
Statins cause musculoskeletal conditions, injuries
Comparing 6,967 statin users with 6,967 nonusers in a military health system, researchers reported in JAMA Internal Medicine that users were 19, 13 and 9 percent more likely to be diagnosed with musculoskeletal disease overall, dislocations, strains and sprains, and musculoskeletal pain.
Drug
Breo Ellipta Approved for COPD Treatment
FDA approved Breo Ellipta, a once-daily inhaled combination of fluticasone furoate and vilanterol, for long-term maintenance treatment of airflow obstruction in COPD and for reducing exacerbations in patients with a history of them.
Drug
How you get treated for colorectal cancer affects survival
In a Cancer analysis of 543 metastatic colorectal cancer patients from a phase 3 trial, those on the conventional 5-fluorouracil, leucovorin and oxaliplatin schedule survived longer than those given the same drugs at set circadian times. Early fatigue and weight loss predicted shorter survival.
Drug
Is There Reason to Worry About New “Most Lethal” Bird Flu Strain?
Mercola argues that WHO and CDC warnings about a new bird flu strain called one of the most lethal are another manufactured emergency, useful for rehearsing the disease surveillance systems built after 9/11 and for justifying the agencies' budgets. Past pandemic threats, he writes, fell short.
Drug
FDA warns pregnant women to not use certain migraine prevention medicines
FDA now contraindicates valproate sodium, valproic acid and divalproex sodium for migraine prevention in pregnancy, moving that use to category X, citing evidence the drugs can lower children's IQ scores. Category D stands for epilepsy and bipolar disorder.
Drug
Despite Doctor’s Order, School Bans Girl for Not Getting Chickenpox Vaccine
A Staten Island kindergartner was barred from school for lacking the chickenpox vaccine, which her pediatrician declined to give out of concern for her baby sister's health. Mercola uses the case to question a schedule of 69 vaccine doses before age 18.
Drug
Why Chemotherapy That Costs $70,000 in the U.S. Costs $2,500 in India
Gleevec costs $70,000 a year in the US and $2,500 in India, where the highest court has again rejected a patent on the leukemia drug. India has also granted compulsory licences letting local firms make generics; Indonesia, China and the Philippines have taken similar steps.
Drug
Your Greatest Weapon Against Breast Cancer (Not Mammograms)
Mercola cites figures that breast cancer diagnoses rose from one in 20 women in 1960 to one in seven today, and points to a December 2011 British Medical Journal study finding screening may harm women, largely through false positives and unnecessary surgery.
Drug
Over 1.3 Million Falsely Diagnosed with This Popular Test
Mercola argues that routine mammography leads to overdiagnosis and unnecessary treatment. An editor's note contends that apparent survival gains can be an artifact of counting from an earlier diagnosis rather than evidence that early treatment helps.
Drug
Mammography can cause breast cancer
A Journal of Clinical Oncology study of 1,601 BRCA1/2 carriers found those ever exposed to chest x-rays were 54 percent more likely to develop breast cancer, with the increase near 100 percent for exposure before 40. The study measured chest x-rays, not mammography itself.
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