A six-year study of 1,652 older African-Americans in Indianapolis found that taking one anticholinergic drug significantly raised the risk of mild cognitive impairment and taking two doubled it. The class covers Benadryl, Tylenol PM and Unisom as well as Paxil and Elavil.
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Drug
Prescription drugs, vaccines and their risks and benefits.
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Drug
The Radically Dangerous Diabetes Drug that Should NEVER Have Been Approved…
Mercola cites New York Times reporting that SmithKline Beecham ran a 1999 study showing its diabetes drug Avandia was riskier to the heart than Actos, never submitted the results to regulators as required, and spent 11 years keeping the heart risks from becoming public.
Drug
FDA Advisory: Avoid Unintentional Exposure of Children and Pets to Evamist (Estradiol Transdermal Spray)
The FDA warns that skin contact with patients who use Evamist can expose children and pets to its estradiol, and says it is reviewing eight reports of unintended exposure in children from 2007 to 2010. Women using the spray should keep children and pets away from the site.
Drug
Overweight? Diet drugs may not be the answer
A skeptical look at weight-loss drugs as an FDA advisory committee weighs Qnexa, running through Fen Phen's withdrawal, Meridia's heart attack and stroke warning, and the gastrointestinal effects of Alli and Xenical, which users say beat placebo by little.
Drug
VA Allows Some Veterans to Use Medical Marijuana
The Department of Veterans Affairs will let veterans in the 14 states where medical marijuana is legal use it for pain without automatically losing prescription painkillers. Doctors may still refuse, and veterans in other states are not covered. Alternative pain relievers follow.
Drug
FDA Okays generic enoxaparin sodium injection
On July 23 the FDA approved the first generic version of Lovenox, enoxaparin sodium injection, an anticoagulant used to prevent deep vein thrombosis. Approval went to Sandoz, over a citizen petition from Sanofi-Aventis asking the agency to withhold it.
Drug
FDA Orders Glaxo to Stop an Avandia Trial
The FDA told GlaxoSmithKline on July 20 to stop enrolling new patients in a trial of the diabetes drug Avandia, while letting the study continue. Public Citizen's Sidney Wolfe called that going only halfway; an FDA advisory panel had voted 20 to 12 to keep the drug on the market.
Drug
How to stop HIV transmission?
Researchers told the International AIDS Conference in Vienna that about 400,000 infants acquire HIV from their mothers each year although antiviral drugs can virtually eliminate transmission. A JAMA study at African clinics points to patients not taking the drugs and gaps in testing.
Drug
New Test Can Predict IVF Success
Stanford researchers built a model predicting IVF success from about a dozen factors, including embryo growth rate, hormonal response and uterine condition, drawn from more than 5,000 cycles run between 2003 and 2008. Age is currently the main predictor used.
Drug
Does Gardasil Actually Increase Your Risk of Cervical Cancer?
Mercola cites information Merck gave the FDA before approval showing that in people already exposed to HPV 16 or 18, Gardasil raised the risk of precancerous lesions or worse by 44.6 percent. FDA recommends no HPV screening before vaccination and required no warning in the package insert.
Drug
Do YOU Take Any of These 11 Dangerous Cholesterol Drugs?
Researchers now say the JUPITER trial's data set 'appears biased' and does not support the reported drop in nonfatal heart attacks and strokes, ABC News reports. Mercola adds that statin side effects - muscle problems, nerve damage, rhabdomyolysis, liver and pancreas trouble - are well documented.
Drug
Radiotherapy promotes cancer invasion and metastasis
A PLoS One study by researchers in Lisbon reports that ionizing radiation delivered in fractionated radiotherapy promoted tumor invasion and metastasis, including in tissue around the tumor. Low doses enhanced endothelial cell migration via VEGF Receptor-2.
Drug
Avandia linked to cardiovascular risk again
An FDA advisory panel split on Avandia: 12 of 33 members voted to withdraw it, 10 to keep it on the market and seven to add warnings. The FDA's David Graham presented findings that the drug raised heart attack, stroke, heart failure and death risk by 9%, 27%, 25% and 14%.
Drug
FDA: Advair Diskus (fluticasone propionate and salmeterol inhalation powder): Stolen Product Warning
Advair Diskus inhalers stolen from a GlaxoSmithKline warehouse in 2009 have turned up in pharmacies. The FDA says lots 9ZP2255 and 9ZP3325 should not be used because storage and handling cannot be assured, and asks patients and pharmacists to report them.
Drug
Both Avandia and Actos may raise fracture risk
Analyzing pharmacy and medical claims over 540 days, researchers found diabetes patients taking Avandia or Actos were 39 percent likelier to suffer a fracture than patients on neither drug, with comparable increases in men. The findings ran in Diabetes, Obesity & Metabolism.
Drug
FDA: Stolen Inhalers Pose Risk
FDA warns consumers not to use Advair Diskus inhalers stolen from a Virginia warehouse in August 2009, after some reached pharmacies. More than 25,000 were taken, and improper storage may have contaminated them or cut their potency. The agency lists two lot numbers to check.
Drug
Prescription Drug Abuse Quadruples Since 1998
A SAMHSA analysis of treatment admissions found a fourfold rise between 1998 and 2008 in admissions involving non-medical use of prescription narcotic painkillers, now, officials say, the second most prevalent form of illicit drug use in the country.
Drug
Angiotensin Receptor Blockers (ARBs): Ongoing Safety Review for Cancer Risk
A published meta-analysis suggested angiotensin receptor blockers may carry a small increase in cancer risk: new cancers occurred in 7.2% of patients taking them versus 6.0% of those who did not, with no significant difference in cancer deaths. FDA says it has reached no conclusion.
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