An experimental NIAID/GSK Ebola vaccine was well tolerated and produced immune responses in all 20 healthy adults in a phase 1 NIH trial, with interim results in the New England Journal of Medicine. NIAID's Anthony Fauci says larger trials will test whether it actually prevents infection.
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Drug
Prescription drugs, vaccines and their risks and benefits.
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Drug
UPDATED Laparoscopic Uterine Power Morcellation in Hysterectomy and Myomectomy: FDA Safety Communication
The FDA warns against laparoscopic power morcellators for most women having a hysterectomy or myomectomy for uterine fibroids, because the devices can spread unsuspected cancerous tissue such as uterine sarcoma beyond the uterus. It urges providers to weigh alternatives.
Drug
Insulin therapy linked to premature death, cardiac events, cancer
A UK study of 6,484 type 2 diabetes patients found each one-unit increase in insulin dose was associated with 54%, 37% and 35% higher risk of death, major cardiovascular events and cancer over 3.3 years. The study was observational and cannot show insulin caused the added risk.
Drug
Study Explains Why Magnesium Sulfate Lowers Seizure Risk linked to Preeclampsia
In a rat model of severe preeclampsia, seizure threshold fell roughly 65 percent and magnesium sulfate reversed the drop. The abstract reports the rats also had greater blood-brain barrier permeability, which magnesium sulfate did not affect, plus signs of neuroinflammation.
Drug
Research Shows Why Antidepressant May Be Effective in Postpartum Depression
Ohio State researchers reported at Neuroscience 2014 that rats stressed during pregnancy showed depressive-like behavior after giving birth and less complex brain structures. Three weeks of the SSRI citalopram cleared the symptoms and restored normal structural complexity in those brain areas.
Drug
Metformin causes more side effects in type 2 diabetics with H. pylori
A Fudan University study gave metformin to 415 people with type 2 diabetes. After four weeks, those also infected with H. pylori were at least twice as likely to report stomach pain, nausea, bloating and appetite loss, and tolerated a lower final dose, 951 mg a day against 1,209 mg.
Drug
Testosterone replacement therapy may help diabetes mellitus type 2
Researchers randomized 85 men aged 41 to 65 with type 2 diabetes to testosterone replacement or placebo alongside diet, exercise and diabetes drugs. After six months the treated group showed greater HbA1c reduction and better lipid profiles. Leptin levels and blood pressure appeared unaffected.
Drug
Avoid These Antibiotics - Unless Your Life Depends Upon It
Mercola argues that fluoroquinolones, the most commonly prescribed class of antibiotics in the U.S., carry a higher potential for serious permanent injury than other antibiotics and should be refused unless necessary. He points to their fluoride component, which he calls a neurotoxin.
Drug
Addiction Therapy for Drugs, Alcohol, Caffeine, and Sugar
Reagan Houston recounts Libby and Stone's 1977 argument that addiction is partly malnutrition, and their protocol of 25 to 85 grams of sodium ascorbate daily with multivitamins and protein. He cites one test in which high-dose vitamin C temporarily cured 30 of 30 addicts.
Drug
Viagra protects the heart beyond the bedroom
Sapienza University of Rome researchers pooled 24 randomized trials covering 1,622 patients in BMC Medicine and report that long-term daily treatment with PDE5 inhibitors, the main ingredient in Viagra, protected the heart with few side effects.
Drug
FDA approves first combination pill to treat hepatitis C
FDA approved Harvoni (ledipasvir and sofosbuvir) for chronic hepatitis C genotype 1 infection, the first combination pill for it and the first approved regimen that does not require interferon or ribavirin. It is the third HCV drug the agency has approved in a year.
Drug
FDA approves Akynzeo for nausea and vomiting associated with cancer chemotherapy
FDA approved Akynzeo, a capsule combining netupitant and palonosetron, to treat nausea and vomiting in patients on cancer chemotherapy, covering both the first 24 hours and the delayed phase from 25 to 120 hours. Two trials enrolled 1,720 participants.
Drug
Caring for Pierced Ears: Tips from Dermatologists
Dermatologist Elizabeth Martin treats newly pierced ears as wounded skin: wash hands before touching them, leave starter earrings in for six weeks or more, clean daily with soap and twice daily with rubbing alcohol, and see a dermatologist if the holes ooze or turn tender and red.
Drug
Heroin overdose deaths increased in many states through 2012
A CDC analysis of death certificates from 28 states, published in MMWR, found heroin overdose deaths rose sharply between 2010 and 2012, though prescription opioids still killed more than twice as many. Earlier research found about 3 in 4 new heroin users had first abused prescription opioids.
Drug
3D Technologies Poised to Change How Doctors Diagnose Cancers
An FDA team studying how clinicians read medical images is evaluating 3D breast tomosynthesis, 3D ultrasound and breast CT as successors to 2D mammography. Two devices already have FDA approval, though the article calls the technology exploratory and years from routine use in doctors' offices.
Drug
Xolair (omalizumab): Drug Safety Communication - Slightly Elevated Risk of Cardiovascular and Cerebrovascular Serious Adverse Events
An FDA safety review found a slightly increased risk of heart and brain blood vessel problems among patients treated with the asthma drug Xolair, and the agency added that information to the label. Cancer rates did not differ, though study limits leave a potential risk unresolved.
Drug
FDA warns consumers not to use Eu Yan Sang (Hong Kong) Ltd.’s “Bo Ying compound"
The FDA warns parents and caregivers not to use Bo Ying compound from Eu Yan Sang (Hong Kong) Ltd., a powder marketed for infants and children, after New York City health officials found high lead levels. One case of poisoning in an 18-month-old has been reported.
Drug
Double mastectomy no better than conservative breast surgery plus radiation
Among 189,734 California women with stage 0-III unilateral breast cancer followed a mean of 89 months, bilateral mastectomy brought no survival gain over breast-conserving surgery with radiation, while unilateral mastectomy carried 35 percent higher death risk.
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