In 559 adolescents aged 14 to 18, Medical College of Georgia researchers correlated high-fructose diets with higher blood pressure, fasting glucose, insulin resistance and inflammatory markers, and with lower HDL and adiponectin. Belly fat worsened the pattern; subcutaneous fat did not.
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Food
Fructose raises risk for kidney disease, hypertension
Reviewing 62 studies, Polish researchers conclude excess fructose may contribute to fatty liver, insulin resistance, dyslipidemia, hypertension and kidney disease. They note fruit brings antioxidants, vitamin C, polyphenols, potassium and fiber that may counter the effect.
Watch-List
Fructose, high fructose corn syrup may increase cardiovascular risk
In a UC Davis study of 48 adults, 24-hour triglycerides, LDL cholesterol and apolipoprotein B rose among those drawing 25 percent of energy from fructose or high fructose corn syrup, but not from glucose. The authors suggest this may raise cardiovascular disease risk.
Food
FINALLY People Starting to Consume Less Sugar!
Added sugar in the US diet fell from about 100 grams a day in 1999-2000 to 77 grams in 2007-2008, mostly from drinking less soda, an analysis of more than 42,000 people found. Mercola adds rat work suggesting free fructose does more metabolic harm than sucrose.
Heart & Blood
This sugar boosts risk of hypertension and a myriad of other conditions
A Current Hypertension Reports review argues fructose can raise blood pressure through several mechanisms, including uric acid produced by its metabolism, and that the risk climbs alongside a high-salt diet because fructose promotes salt and water reabsorption.
Food
High fructose corn syrup may boost risk of diabetes mellitus, cardiovascular disease
Rats given sugary drinks for 56 days built up more abdominal fat, higher triglycerides and impaired insulin and glucose control than rats drinking water, despite similar body weight. Only the fructose-glucose group showed raised fasting glycaemia, a pre-diabetes sign.
Food
More evidence suggests fructose boosts heart disease risk
Adults who took 25 percent of their calories from fructose or high fructose corn syrup for just two weeks showed higher LDL cholesterol, triglycerides and apolipoprotein-B. Glucose produced no such change. US dietary guidelines allow added sugar up to that same 25 percent.
Food
Eating fructose linked to high risk of fatty liver disease?
Among 149 children with fatty liver disease, those with definite NASH showed high fructose intake, judged from uric acid levels. Low vitamin E tracked with more steatosis and low vitamin C with more ballooning degeneration. The study did not directly link fructose intake to the disease.
Food
Who says fructose promotes obesity?
In a six-week Mexican trial of 131 obese patients, both energy-restricted diets produced significant weight loss, but the one with 50 to 70 grams of natural fructose a day led to more of it: 4.19 pounds against 2.83 pounds on the low-fructose diet.
Food
Fructose Fuels Cancer More Than Other Sugars
A UCLA study found pancreatic cancer cells handled fructose and glucose differently and used fructose more readily to divide and proliferate, which the author takes as a reason for people fighting cancer to cut their fructose intake.
Food
Sugar-sweetened drinks may boost blood pressure
Among 2,696 adults across eight U.S. and two U.K. areas, each daily serving of a sugar-sweetened drink was associated with systolic pressure 1.6 mm Hg higher and diastolic 0.8 mm Hg higher, with a stronger link at high sodium intake. Diet sodas showed no association.
Food
Fructose-rich sodas, orange juice boost gout risk in women too
Among 78,906 women followed 22 years, those drinking one serving a day of a fructose-rich beverage were 41% more likely to develop gout, and those having two or more servings 2.4 times more likely. Orange juice showed the same pattern; diet soft drinks showed no link.
Cancer
Cancer's Favorite Food - Found in Everything You Eat?
A Cancer Research study found pancreatic tumor cells handle fructose and glucose in different ways, using fructose to divide and proliferate. The finding challenges the idea that all sugars act alike and may bear on earlier links between fructose and pancreatic cancer.
Food
Fructose promotes growth of pancreatic cancer
UCLA researchers compared how pancreatic cancer cells in Petri dishes use glucose and fructose, and found the cells route fructose through the non-oxidative pentose phosphate pathway to build nucleic acids for division. Lead author Anthony Heaney calls refined sugar a hidden danger.
Food
The Hidden and Pervasive Cause of High Blood Pressure
A study of 4,528 US adults with no prior history of hypertension linked diets high in fructose to increased risk of high blood pressure. The results suggest that cutting back on fructose-sweetened foods and drinks might lower that risk.
Food
High intake of fructose may raise blood pressure
Analysing sugar intake among more than 4,500 adults, Colorado researchers found people eating 74 grams or more of fructose a day had 26% to 77% higher odds of elevated blood pressure, depending on the cutoff. The study could not separate the effects of fructose and glucose.
Food
Can This Popular Alternative Sweetener Spike Uric Acid into the Danger Zone?
Dr. Mercola argues that most agave is worse than high-fructose corn syrup and defends his earlier report against industry criticism, saying he sells no competing sweetener. He suggests stevia, small amounts of xylitol, or dextrose, and had three agave products independently tested.
Food
This Popular Drink May Be Almost as Hazardous to Your Health as Soda
Mercola names fruit juice as the drink in question and talks with Dr. Richard Johnson of the University of Colorado, who researches how the fructose flooding the American diet contributes to obesity, high blood pressure and diabetes.
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