A double-blind Brazilian trial of 60 postmenopausal women found a soy supplement with 90 mg of isoflavone and hormone therapy improved hot flashes and muscle pain similarly, by 49.8 and 45.6 percent at 16 weeks. The authors say soy may be an effective alternative.
Section archive
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Cancer
Breast Cancer Risk: One Size May Not Fit All
USC researchers tracking 3,000 women from 1995 to 2006 found 15 years or more of estrogen therapy raised breast cancer risk 19%, and estrogen with progestin raised it 83%. Thinner women faced greater post-HRT risk than obese women, which the team did not explain.
Drug
Hormone replacement therapy boosts breast cancer risk, study confirms
Following almost 3,000 women for about 10 years, USC researchers found breast cancer risk climbed the longer hormone therapy lasted: 19% higher after 15 years of estrogen alone, 83% higher with estrogen plus progestin. Continuous users faced the highest risk of all.
Drug
HRT Increases Ovarian Cancer Risk
A Danish study reported in JAMA found women on hormone replacement therapy had a 38 percent greater risk of ovarian cancer than never-users. The absolute risk stays low, about one extra case per 8,300 women, and returns to normal two years after stopping.
Drug
HRT confirmed to increase heart attack risk in women
US heart attacks have fallen since the 2002 Women's Health Initiative warning drove HRT use among women aged 50-59 from 30 percent to under 15 percent, by RAND's count 25 fewer per 10,000 a year. Cardiologist Nieca Goldberg says it is premature to credit HRT's decline alone.
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