A two-year US trial giving about 200 women 200 mg of soy isoflavones daily found they were actually more likely to report hot flashes. But a Brazilian trial using 90 mg cut hot flashes by almost half and eased vaginal dryness by over 30%, and an Ecuadorian study found fewer, milder episodes.
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Nutrition
One study says soy isoflavones don't help hot flashes, another study says they do
A two-year randomized trial of 248 women aged 45 to 60 found 200 mg a day of soy isoflavones did not prevent bone loss or menopausal symptoms, and women taking them reported more hot flashes and constipation. An earlier Brazilian trial reached the opposite conclusion.
Phytochemicals
Soy food doesn't affect breast cancer survival
Pooling four cohorts covering 18,312 women with invasive breast cancer, Vanderbilt's Xiao Ou Shu found those eating more than 23 mg of soy isoflavones daily were 9 percent less likely to die and 15 percent less likely to relapse. Neither result reached statistical significance.
Food
Eating soybean may reduce risk of breast cancer
Women with the highest soy isoflavone intake were 30% less likely to have an invasive breast cancer, in a comparison of 683 breast cancer patients with 611 healthy women. The associations showed up only among premenopausal women, and the design cannot establish cause.
Supplements
Soy supplements as effective as hormone therapy in easing menopausal symptoms
In a double-blind trial, 60 postmenopausal women took a 90 mg soy isoflavone supplement or hormone therapy for 16 weeks. Both eased hot flashes and muscle pain, by 49.8 and 45.6 percent, and vaginal dryness. Placebo matched them except on urogenital symptoms.
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